Therapygenetics: 5-HTTLPR genotype predicts the response to exposure therapy for agoraphobia |
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| Affiliation: | 1. School for Mental Health en Neuroscience, Maastricht University and Mondriaan, Vijverdalseweg 1, gebouw Concorde, 6226 NB Maastricht, The Netherlands;2. School for Mental Health en Neuroscience, Maastricht University,Maastricht, The Netherlands;1. Department of Urology, University Hospital Carl Gustav Carus, Dresden, Germany;2. Department of Medical Statistics and Biometry, University Hospital Carl Gustav Carus, Dresden, Germany;3. Department of Anesthesiology, University Hospital Carl Gustav Carus, Dresden, Germany;1. University of Haifa, Haifa, Israel;2. Department of Information and Evaluation, Ministry of Health, Jerusalem, Israel;3. Departments of Psychiatry and Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA;1. School of Life Sciences, University of Skövde, Sweden;2. Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Nursing, Stockholm, Sweden;3. Umeå University, Department of Nursing, Umeå, Sweden;4. The Sahlgrenska Academy, University of Gothenburg, Institute of Health and Care Sciences, Gothenburg, Sweden;1. Dirección de planificación, Badalona Serveis Assistencials SA, Badalona, Barcelona, Spain;2. Documentación médica, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain;3. Dirección médica, Badalona Serveis Assistencials SA, Badalona, Barcelona, Spain |
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| Abstract: | This study was intended to assess the extent to which the low-expression allele of the serotonin transporter gene promoter predicts better response to exposure-based behavior therapy in patients with panic disorder with agoraphobia (PDA). Ninety-nine patients with PDA underwent a 1-week in vivo exposure-based behavior therapy program and provided saliva samples to extract genomic DNA and classify individuals according to four allelic forms (SA, SG, LA, LG) of the 5-HTT-linked polymorphic region (5-HTTLPR). We determined whether the 5-HTTLPR genotype predicted change in avoidance behavior in PDA following treatment. After controlling for pre-treatment avoidance behavior, the 5-HTTLPR low-expression genotypes showed a more favorable response to exposure therapy two weeks following treatment, compared to the other patients. This study suggests a genetic contribution to treatment outcome following behavior therapy and implicates the serotonergic system in response to exposure-based treatments in PDA. |
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| Keywords: | Behavior therapy Exposure therapy Genetics Panic disorder Agoraphobia Serotonin |
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