Severity of psychosis syndrome and change of metabolic abnormality in chronic schizophrenia patients: Severe negative syndrome may be related to a distinct lipid pathophysiology |
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| Affiliation: | 1. Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan;2. Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan;3. Yu-Li Veterans Hospital, Yu-Li Town, Hualian County, Taiwan;4. Faculty of Medicine, National Yang Ming University, Taipei, Taiwan;5. Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan;6. Chung Hwa University of Medical Technology, Tainan, Taiwan;7. Jianan Mental Hospital, Tainan, Taiwan;8. Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan;1. Institute of Brain, Behaviour and Mental Health, The University of Manchester, Manchester, M13 9PL, United Kingdom;2. Mental Health Unit, Laureate House, Manchester Mental Health & Social Care Trust, Wythenshawe Hospital, Southmoor Road, Manchester, United Kingdom;3. Centre for Biostatistics, Institute of Population Health, The University of Manchester, Manchester, United Kingdom;4. Centre for Mental Health, Imperial College London, Charing Cross Campus, London, United Kingdom;5. Department of Psychiatry & CPFT, University of Cambridge, Cambridge, United Kingdom;1. Neurogenetics Group, Division of Brain Sciences, Faculty of Medicine, Imperial College London, United Kingdom;2. University of Hull and NAViGO, Hull, United Kingdom;3. Benito Menni Complex Assistencial en Salut Mental, Germanes Hospitalàries del Sagrat Cor de Jesús, C/Doctor Antoni Pujades 38-C, 08830 Sant Boi de Llobregat, Barcelona, Spain;1. Institute of Behavioral Medicine, National Cheng Kung University Hospital, Tainan, Taiwan;2. Department of Psychiatry, National Cheng Kung University & Hospital, Tainan, Taiwan;3. Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan;4. Addiction Research Center, National Cheng Kung University, Tainan, Taiwan;5. Department of Psychiatry, Tainan Hospital, Department of Health, Executive Yuan, Tainan, Taiwan;6. Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;1. INSERM 669, Paris-Sud University and Paris-Descartes University, Maison des Adolescents, 97, boulevard de Port-Royal, 75014 Paris, France;2. PRA Structure - Économie de la Santé, Lilly France, 17, rue Pagès, 92150 Suresnes, France;3. Zurich University Psychiatric Hospital, Lenggstr. 31, Mail Box 68, CH-8029 Zurich, Switzerland;4. Service de psychiatrie adulte, Sainte-Marguerite University Hospital Centre, 270, boulevard de Sainte-Marguerite, 13009 Marseille, France;5. Département de Psychiatrie et d’Addictologie, Paul Brousse Hospital, 12, avenue Paul-Vaillant-Couturier, 94804 Villejuif cedex, France;6. Lilly Research Centre, Eli Lilly and Company Limited, Erl Wood Manor, Sunninghill road, Windlesham, Surrey, GU20 6PH, United Kingdom;7. Direction de la Politique Médicale, Assistance Publique–Hôpitaux de Paris, 3, avenue Victoria, 75004 Paris, France;1. Department of Neurosurgery, St. Vincent Hospital, The Catholic University of Korea, Suwon, Republic of Korea;2. Department of Neurosurgery, Incheon St. Mary’s Hospital, The Catholic University of Korea, Republic of Korea |
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| Abstract: | BackgroundMetabolic abnormality is common among schizophrenia patients. Some metabolic traits were found associated with subgroups of schizophrenia patients.ObjectivesWe examined a possible relationship between metabolic abnormality and psychosis profile in schizophrenia patients.MethodThree hundred and seventy-two chronic schizophrenia patients treated with antipsychotics for more than 2 years were assessed with the Positive and Negative Syndrome Scale. A set of metabolic traits was measured at scheduled checkpoints between October 2004 and September 2006.ResultsMultiple regressions adjusted for sex showed negative correlations between body mass index (BMI) and total score and all subscales; triglycerides (TG) was negatively correlated with total score and negative syndrome, while HDLC was positively correlated with negative syndrome. When sex interaction was concerned, total score was negatively correlated with BMI but not with others; negative syndrome was negatively correlated with BMI and positively with HDLC. No metabolic traits were correlated with positive syndrome or general psychopathology.ConclusionsLoss of body weight is a serious health problem in schizophrenia patients with severe psychosis syndrome, especially the negative syndrome. Schizophrenia patients with severe negative syndrome may have a distinct lipid pathophysiology in comparison with those who were less severe in the domain. |
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| Keywords: | Schizophrenia Psychosis Metabolism Lipid Glucose |
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