The effects of acute pharmacological stimulation of the 5-HT,NA and DA systems on the cognitive judgement bias of rats in the ambiguous-cue interpretation paradigm |
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| Institution: | 1. School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, South Australia, Australia;2. School of Pharmacy and Medical Sciences, University of South Australia, City East Campus, South Australia, Australia;3. Gastroenterology Department, Children, Youth and Women''s Health Services, Adelaide, South Australia, Australia |
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| Abstract: | In the present study, we investigated the effects of acute pharmacological stimulation of the serotonergic (5-HT), noradrenergic (NA) and dopaminergic (DA) systems on the valence of cognitive judgement bias of rats in the ambiguous-cue interpretation (ACI) paradigm. To accomplish this goal, after initial behavioural training, different groups of rats received single injections of citalopram, desipramine or d-amphetamine and were subsequently tested with the ACI paradigm. Each drug was administered in 3 doses using a fully randomised Latin square design. Citalopram at the dose of 1 mg/kg significantly biased animals towards positive interpretation of the ambiguous cue, while at higher doses (5 and 10 mg/kg), the animals interpreted the ambiguous cue more negatively. Desipramine at all 3 tested doses (1, 2 and 5 mg/kg) significantly biased animals towards negative interpretation of the ambiguous cue, while d-amphetamine at the dose of 1 mg/kg induced positive bias, having no effects at lower doses (0.1 and 0.5 mg/kg). Our results indicate that cognitive bias in rats can be influenced by acute pharmacological intervention. |
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| Keywords: | Rat Cognitive bias Ambiguous-cue Desipramine Citalopram |
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