Disrupted action monitoring in recent-onset psychosis patients with schizophrenia and bipolar disorder |
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| Affiliation: | 1. Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, CA, United States;2. Department of Psychiatry, University of California, Davis School of Medicine, Sacramento, CA, United States;3. Department of Psychology, University of California, Davis, CA, United States;1. Mental Health Sciences Unit, Faculty of Brain Sciences, University College London, United Kingdom;2. Institute of Biomedical Research (IBSAL), Salamanca, Spain;3. Neuroscience Institute of Castilla y León, University of Salamanca, Salamanca, Spain;4. UCM-ISCIII Center for Human Evolution and Behavior, Madrid, Spain;5. Basic Psychology, Psychobiology and Methodology Department, School of Psychology, University of Salamanca, Salamanca, Spain;6. Psychiatry Service, University Hospital of Valladolid, Valladolid, Spain;7. Psychiatry Department, School of Medicine, University of Valladolid, Valladolid, Spain;1. State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases, Fourth Military Medical University, China;2. Department of Gastroenterology, Xi’an Children''s Hospital, China;3. Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, China;4. Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, China;1. L2MSP, Department of physics, University of Dschang, PO Box 67, Dschang, Cameroon;2. LISIE, University Institute of Technology Fotso Victor, University of Dschang, PO Box 134, Bandjoun, Cameroon;1. Physiological department, CHU Lariboisière Fernand-Widal, AP–HP, Paris Diderot university, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France;2. Neurology department and stroke unit, CHU Lariboisière Fernand-Widal, AP–HP, Paris Diderot university, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France;3. Ophthalmology department, CHU Lariboisiere Fernand-Widal, AP–HP, Paris Diderot university, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France;4. Clinical research unit, CHU Lariboisière Fernand-Widal, AP–HP, Paris Diderot university, 2, rue Ambroise-Paré 75475 Paris cedex 10, France;5. Inserm U740, faculty of medicine, university Paris Diderot, Paris, France;1. Olin Neuropsychiatry Research Center, Hartford Hospital (IOL campus), Hartford, Connecticut;2. Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, New Mexico;3. Department of Psychology, University of Georgia, Athens, Georgia;4. Department of Psychiatry, UT Southwestern Medical School, Dallas, Texas;5. Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts;6. Department of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, Connecticut;1. Key Laboratory of Semiconductor Materials Science, Institute of Semiconductors, Chinese Academy of Sciences, P.O. Box 912, Beijing 100083, People''s Republic of China;2. Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices, Institute of Semiconductors, Chinese Academy of Sciences, P.O. Box 912, Beijing 100083, People''s Republic of China |
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| Abstract: | Schizophrenia patients experience cognitive control disturbances, manifest in altered neural signatures during action monitoring. It remains unclear whether error- and conflict-monitoring disturbances co-occur, and whether they are observed in recent-onset psychosis patients with schizophrenia or bipolar disorder. We tested electrophysiological measures of action monitoring in these patients. Seventy-three schizophrenia patients (SZ), 26 bipolar disorder type I patients (BP), each within one year of psychosis onset, and 54 healthy control subjects (HC) underwent EEG during Stroop task performance. In the trial-averaged EEG at three midline scalp electrodes, the error-related negativity (ERN), error positivity (Pe) and conflict-related N450 were measured. Compared to HC (1) SZ exhibited an attenuated ERN and N450, and Pe unchanged and (2) BP exhibited an attenuated ERN but normal Pe and N450. Between patient groups, SZ showed an attenuated N450; ERN and Pe were not significantly different. A small (n=10) SZ subgroup that was not receiving antipsychotic medication showed normal ERPs. Altered error- and conflict-monitoring occur together in the first-episode schizophrenia patients, and these measures are comparable in patients with the first-episode bipolar disorder. Antipsychotic medication may be associated with altered measures of error-monitoring in schizophrenia. |
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| Keywords: | Error-related negativity Error positivity N450 Conflict Performance adjustment Stroop |
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