Multi-step lung carcinogenesis model induced by oral administration of N-nitrosobis(2-hydroxypropyl)amine in rats |
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| Affiliation: | 1. Division of Cancer Biology and Bioinformatics, Department of Life Science, Faculty of Science and Engineering, Kinki University, 3-4-1, Kowakae, Higashiosaka, Osaka 577-8502, Japan;2. Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health, 3-24-1 Hyakunin-cho, Shinjuku-ku, Tokyo 169-0073, Japan;3. Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8501, Japan;4. Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104, USA;1. Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal;2. Research Center in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport Sciences, University of Porto, Porto, Portugal;3. Organic Chemistry of Natural Products and Agrifood, Mass Spectrometry Center, Department of Chemistry, University of Aveiro, Aveiro, Portugal;4. Animal and Veterinary Research Center (CECAV), University of Trás-os-Montes and Alto Douro, Vila Real, Portugal;5. Center for the Study of Animal Sciences (CECA), University of Porto, Porto, Portugal;1. Institute of Electronics, Bulgarian Academy of Sciences, 72 Tsarigradsko Chausse, 1784 Sofia, Bulgaria;2. Institute of Electrical Engineering, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovak Republic;3. Institute of Solid State Physics, Russian Academy of Sciences, 142432 Chernogolovka, Moscow, Russia;1. Bioinformatics Lab, Healthcare Group, SK Telecom, 9-1, Sunae-dong, Pundang-gu, Sungnam-si, Kyunggi-do 463-784, Republic of Korea;2. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea;3. Department of Biological Science, Seoul National University, 599 Gwanakro, Gwanak-gu, Seoul 151-747, Republic of Korea;4. Department of New Drug Discovery and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 305-764, Republic of Korea;5. Bioneer Corp., 8-11 Munpyeongseo-ro, Daedeok-gu, Daejeon 306-220, Republic of Korea;6. Department of Applied Biology, Gyeongsang National University, 501 Jinju-daero, Jinju, Gyeongnam 660-701, Republic of Korea;7. Aging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-Gu, Daejeon 305-806, Republic of Korea;8. Department of Obstetrics and Gynecology, Inha University Hospital, 7-206 Sinheung-dong, Jung-gu, Incheon 400-711, Republic of Korea;1. Department of Library and Information Science, Fu Jen Catholic University, 510 Jhongjheng Rd., Sinjhuang Dist., New Taipei City 24205, Taiwan, ROC;2. Graduate Institute of Networking and Multimedia, National Taiwan University, #1 Roosevelt Rd., Sec. 4, Taipei 106, Taiwan, ROC;3. Department of Photonics & Communication Engineering, Asia University, No. 500, Lioufeng Road, Wufeng Shiang, Taichung 402, Taiwan, ROC |
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| Abstract: | N-Nitrosobis(2-hydroxypropyl)amine (BHP) was first synthesized by Krüger et al. (1974), and has been shown to primarily induce pancreatic duct adenocarcinomas by a subcutaneous injection in Syrian hamsters. By contrast, the carcinogenic effect of BHP has been indicated at the different target organs in rats, namely the lung. When rats are received by an oral administration of BHP in drinking water for 25 weeks, a high incidence of lung carcinomas are induced, which include adenocarcinomas, squamous cell carcinomas and combined squamous cell and adenocarcinomas. So many similarities are observed in terms of not only histological appearances but also gene alterations between human and BHP-induced rat lung cancers. Moreover, the step by step development of lung lesions, from preneoplastic lesions to cancers in rat lung carcinogenesis by BHP offers a good model to investigate the mechanisms underlying the pathogenesis of lung cancers. Because data for genetic and epigenetic alterations have indeed been accumulated during the BHP-induced rat lung carcinogenesis, we will introduce them in this review and hence demonstrate that this lung carcinogenesis model provides a useful opportunity for the research on the pathogenesis of lung cancers of both humans and rats. |
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| Keywords: | Multi-step carcinogenesis Lung Oral administration Rat |
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