Ibuprofen Potentiates the In Vivo Antifungal Activity of Fluconazole against Candida albicans Murine Infection |
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| Authors: | Sofia Costa-de-Oliveira Isabel M. Miranda Ana Silva-Dias Ana P. Silva Acácio G. Rodrigues Cidália Pina-Vaz |
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| Affiliation: | aDepartment of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal;bCINTESIS—Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal;cBurn Unit, Department of Plastic and Reconstructive Surgery, Hospital São João, Porto, Portugal;dDepartment of Microbiology, Hospital São João, Porto, Portugal |
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| Abstract: | Candida albicans is the most prevalent cause of fungemia worldwide. Its ability to develop resistance in patients receiving azole antifungal therapy is well documented. In a murine model of systemic infection, we show that ibuprofen potentiates fluconazole antifungal activity against a fluconazole-resistant strain, drastically reducing the fungal burden and morbidity. The therapeutic combination of fluconazole with ibuprofen may constitute a new approach for the management of antifungal therapeutics to reverse the resistance conferred by efflux pump overexpression. |
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