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A single nucleotide polymorphism in SLC1A1 gene is associated with age of onset of obsessive-compulsive disorder
Affiliation:1. National Institute for Health and Welfare, Finland;2. Social Insurance Institution, Finland;1. Centro de Investigación en Biología Molecular y Celular, Universidad de Costa Rica, San José, Costa Rica;2. Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA;3. Center of Excellence for Neurosciences, Texas Tech University Health Science Center, El Paso, TX, USA;4. Escuela de Biología, Universidad de Costa Rica, San José, Costa Rica;5. Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA;6. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA;1. Anthropology Unit, Department of Animal Biology, Faculty of Biology, University of Barcelona and Biomedicine Institute of the University of Barcelona (IBUB), Avenue Diagonal, 643, 08028 Barcelona, Spain;2. Centre for Biomedical Research Network on Mental Health (CIBERSAM), Doctor Esquerdo, 46, 28007 Madrid, Spain;3. Department of Psychiatry, Alava University Hospital (Santiago), EHU/UPV, Kronikgune, Olaguibel 29, Vitoria, Spain;4. Department of Psychiatry and Psychotherapy, Jena University Hospital, 07743 Jena, Germany;1. Department of Neurology, The First Affiliated Hospital at Chongqing Medical University, 1, Yixue Road, Yuzhong District, Chongqing, 400016, China;2. Chongqing Key Laboratory of Neurobiology, Chongqing, China;3. Institute of Neuroscience, Chongqing Medical University, Chongqing, China;4. Department of Neurology, The Fifth People''s Hospital of Chongqing, Chongqing, China;1. Alcoholism Unit, Department of Internal Medicine, University Hospital of Salamanca, Salamanca, Spain;2. Molecular Medicine Unit, Department of Medicine, University of Salamanca, Salamanca, Spain;3. Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain;1. Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori-ichibancho, Chuo-ku, Niigata 951-8510, Japan;2. Division of Medical Education, Comprehensive Medical Education Center, School of Medicine, Faculty of Medicine, 757 Asahimachidori-ichibancho, Chuo-ku, Niigata 951-8510, Japan;1. Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori-ichibancho, Chuo-ku, Niigata 951-8510, Japan;2. Health Administration Center, Headquarters for Health Administration, Niigata University, 8050 Ikarashi-ninocho, Nishi-ku, Niigata 950-2181, Japan
Abstract:Different genetic polymorphisms in the SLC1A1 have been shown to be associated with obsessive-compulsive disorder. Rs301430 is a T/C functional polymorphism affecting the gene expression and extrasynaptic glutamate concentration.We observed that Rs301430 influence age at onset in obsessive-compulsive disorder.
Keywords:Obsessive-compulsive disorder  Age at onset  Rs301430  Glutamate
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