Flow-mediated dilation,carotid wall thickness and HDL function in subjects with hyperalphalipoproteinemia |
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| Affiliation: | 1. Medical Department, Azienda Ospedaliera-Universitaria di Ferrara, Ferrara, Italy;2. Department of Pharmacy, University of Parma, Parma, Italy;3. Department of Medical Sciences, University of Ferrara, Ferrara, Italy;4. Department of Life Sciences, University of Modena & Reggio Emilia, Modena, Italy;1. Service d’Ophtalmologie, Hôpital Robert-Debré, Centre Hospitalo-Universitaire, 51092 Reims, France;2. Pôle Thoracique, Cardio-Vasculaire et Neurologique, Centre Hospitalo-Universitaire, 51092 Reims, France;3. Laboratoire Pol Bouin, Hôpital Maison-Blanche, Centre Hospitalo-Universitaire, 51092 Reims, France;4. Service d’Endocrinologie, Maladies Métaboliques et de Médecine Interne, Hôpital Robert-Debré, Centre Hospitalo-Universitaire, 51092 Reims, France;5. Cardiovascular Research Institute, 555, Mission Bay Boulevard South Room 252A, Box 311, San Francisco, CA 94158, USA;1. Division of Hematology, Oncology and Stem Cell Transplant, Department of Pediatrics, Ann & Robert H Lurie Children''s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;2. Stanley Manne Children''s Research Institute, Ann & Robert H Lurie Children''s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;3. Division of Neonatology, Department of Pediatrics, Ann & Robert H Lurie Children''s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;4. Children''s Hospital Association, Lenexa, KS, USA;1. Department of Immunology, 2nd Faculty of Medicine, Charles University, University Hospital in Motol, Prague, Czech Republic;2. Department of Pediatrics, 2nd Faculty of Medicine, Charles University, University Hospital in Motol, Prague, Czech Republic;3. Department of Pediatrics and Adolescent Medicine, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic;4. Sotio a.c., Prague, Czech Republic;1. Unidad de Hemodinámica, Sección de Cardiología, Hospital Universitario de San Juan de Alicante, San Juan de Alicante, Alicante, Spain;2. Sección de Cardiología, Hospital Marina Baixa, Villajoyosa, Alicante, Spain;3. Unidad de Hemodinámica, Sección de Cardiología, Hospital General de Elche, Elche, Alicante, Spain |
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| Abstract: | Background and aimsThe relationships between very high plasma HDLc and subclinical atherosclerosis are still a matter of debate.Methods and resultsTwenty subjects with primary hyperalphalipoproteinemia (HAL, with HDLc in the highest 10th percentile and absence of overt secondary causes of this condition), aged 30–65 years, were compared with 20 age and sex-matched controls. Lipid determination, lipoprotein particle distribution (Lipoprint®), Cholesterol Efflux Capacity (CEC), plasma adhesion molecule, analyses of CETP, SRB1 and LIPG genes and of different markers of subclinical vascular disease (ankle-brachial index, ABI; carotid intima-media thickness, cIMT; brachial-artery flow mediated dilation, FMD) were performed. Fasting HDLc levels were 40 mg/dl higher in HAL subjects while LDLc concentration was comparable to control group. CETP gene analysis in HAL subjects identified one novel rare Single Nucleotide Polymorphism (SNP, Asp131Asn), possibly damaging, while the common SNP p.Val422Ile was highly prevalent (50% vs. 27.4% in a control population). No rare mutations associated with HAL were found in SR-B1 and LIPG genes. Polyacrylamide gel electrophoresis in HAL subjects disclosed larger and more buoyant HDL particles than in controls, while LDL profile was much more similar. ABI, cIMT and arterial plaques did not differ in cases and controls and the two groups showed comparable FMD at brachial artery examination. Similarly, ABCA1 and ABCG1 HDL-mediated CEC, the most relevant for atheroprotection, did not discriminate between the groups and only ABCG1 pathway seemed somewhat related to arterial reactivity.ConclusionsHDL dimension, function and genetics seem scarcely related to subclinical atherosclerosis and vascular reactivity in middle-aged HAL subjects. |
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| Keywords: | Hyperalphalipoproteinemia HDL Lipoprotein subfractions Flow-mediated dilation Cholesterol-efflux capacity |
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