Cognitive effects of methylphenidate and levodopa in healthy volunteers |
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| Affiliation: | 1. UMR1027 Inserm—Université Paul Sabatier Toulouse III, Toulouse, France;2. Département Universitaire de Médecine Générale, Faculté de Médecine, Université Paul Sabatier Toulouse III, Toulouse, France;3. CEIP-Addictovigilance, CHU Toulouse, Toulouse, France;1. School for Mental Health and Neuroscience, Department of Neuroscience, Maastricht University, Universiteitssingel 40, NL 6229ER Maastricht, Netherlands;2. GIGA Neuroscience, University of Liege, Avenu de l’Hopital 1, B36 4000 Liege, Belgium;3. Institute of Physiologically Active Compounds, Laboratory of Neurochemistry, Russian Academy of Sciences, Chernogolovka, Severnii proesd 1, 142432 Moscow Region, Russia;1. Department of Internal Medicine, SS Annunziata Hospital, Cento, Ferrara, Italy;2. “G. Fontana” Centre for the Study and Multidisciplinary Treatment of Alcohol Addiction, Department of Clinical Medicine, University of Bologna, Italy;3. Unit for Addiction Treatment, Department of Mental Health, Lugo, Ravenna, Italy;4. Department of Addictive Behaviours, Dolo, Venice, Italy;5. Institute of Internal Medicine, Catholic University of Rome, Italy;1. Institute of Anatomy and Cell Biology, Universitätsmedizin Greifswald, Friedrich Löffler Straße 23c, 17487 Greifswald, Germany;2. Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland;3. Department of Pediatric Surgery, Centre for Fetal Medicine, Division of Women and Child Health, University of Leipzig, Leipzig, Germany;4. Department of Obstetrics, Centre for Fetal Medicine, Division of Women and Child Health, University of Leipzig, Leipzig, Germany;1. PET Centre, Department of Medical Imaging, Uppsala University Hospital, S-751 85 Uppsala, Sweden;2. Section of Nuclear Medicine and PET, Department of Radiology, Oncology, and Radiation Sciences, Uppsala University, Uppsala, Sweden;3. Department of Pharmaceutical Sciences, Uppsala University, Uppsala, Sweden;4. NeuroSearch A/S, Pederstrupvej 93, DK-2750 Ballerup, Denmark;5. Department of Biochemistry and Organic Chemistry, Uppsala University, Uppsala, Sweden;6. Department of Nuclear Medicine, PET & Cyclotron Unit, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark |
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| Abstract: | Our previous study showed enhanced declarative memory consolidation after acute methylphenidate (MPH) administration. The primary aim of the current study was to investigate the duration of this effect. Secondary, the dopaminergic contribution of MPH effects, the electrophysiological correlates of declarative memory, and the specificity of memory enhancing effects of MPH to declarative memory were assessed. Effects of 40 mg of MPH on memory performance were compared to 100 mg of levodopa (LEV) in a placebo-controlled crossover study with 30 healthy volunteers. Memory performance testing included a word learning test, the Sternberg memory scanning task, a paired associates learning task, and a spatial working memory task. During the word learning test, event-related brain potentials (ERPs) were measured. MPH failed to enhance retention of words at a 30 min delay, but it improved 24 h delayed memory recall relative to PLA and LEV. Furthermore, during encoding, the P3b and P600 ERP latencies were prolonged and the P600 amplitude was larger after LEV compared to PLA and MPH. MPH speeded response times on the Sternberg Memory Scanning task and improved performance on the Paired Associates Learning task, relative to LEV, but not PLA. Performance on the Spatial working memory task was not affected by the treatments. These findings suggest that MPH and LEV might have opposite effects on memory |
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| Keywords: | Memory Event-related potentials Dopamine Methylphenidate Levodopa |
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