Leveraging the Pre-DFG Residue Thr-406 To Obtain High
Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series |
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| Authors: | Joachim Rudolph,Ignacio Aliagas,James
J. Crawford,Simon Mathieu,Wendy Lee,Qi Chao,Ping Dong,Lionel Rouge,Weiru Wang,Christopher Heise,Lesley J. Murray,Hank La,Yanzhou Liu,Gerard Manning,Fran?ois Diederich,Klaus P. Hoeflich |
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| Affiliation: | †Genentech, 1 DNA Way, South San Francisco, California 94080, United States;‡ShanghaiChempartner, Inc., 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, People’s Republic of China;§ETHZürich, Vladimir-Prelog-Weg 3, CH-8093 Zürich, Switzerland |
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| Abstract: | | |
| Keywords: | Pre-DFG residue PAK1 kinase aminopyrazole |
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