GDNF and GFRα co-receptor family in the developing feline gut |
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| Institution: | 1. Department of Dental Materials, School of Dentistry, Research Center of Nano-Interface Activation for Biomaterials, Chosun University, South Korea;2. Biomechanics & Tissue Engineering Laboratory, Division of Orthodontics, College of Dentistry, The Ohio State University, Columbus, OH, USA;3. Division of Restorative, Prosthetic and Primary Care Dentistry, College of Dentistry, The Ohio State University, Columbus, OH, USA;1. Earth Sciences Centre, Mineralogy–Petrology, Göteborg University, Box 460, SE-405 30 Göteborg, Sweden;2. Isotope Geosciences Unit, S.U.E.R.C., East Kilbride, Glasgow G75 0QF, Scotland, United Kingdom;3. Department of Geological Sciences, Stockholm University, SE-106 91 Stockholm, Sweden;4. Geological Survey of Sweden, Guldhedsgatan 5A, SE-413 20 Göteborg, Sweden |
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| Abstract: | Glial cell-line derived neurotrophic factor (GDNF) and the GFRα co-receptors play a role in the developing enteric nervous system. The co-receptors elicit their action by binding receptor tyrosine kinase RET.This immunohistochemical study reports the presence of GDNF and its specific co-receptor GFRα1 in the cat gastrointestinal apparatus during development, from stage 9 to 22. At stage 9 and 11, immunoreactivity (IR) to GDNF was observed in the cells of mesenchyme of the anterior gut. From stage 14 to 22, GDNF IR was detected in nervous plexuses; moreover, GDNF and GFRα1 IR appeared localized in gastrointestinal endocrine cells. The presence of GDNF in the enteric nervous system and in the endocrine cells suggests an involvement of this neurotrophic factor in the gastrointestinal development. Moreover, the presence of the co-receptor GFRα1 in endocrine cells and its absence in the enteric nervous system seems to indicate a different mode of transduction of GDNF signal. GFRα2 and GFRα3 co-receptors were not detected. |
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| Keywords: | Neurotrophic factor Intestine Stomach Enteric nervous system Endocrine cells |
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