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Harmful and beneficial relationships between alcohol consumption and subclinical atherosclerosis |
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| Institution: | 1. Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan, South Korea;2. Department of R&D, Daily Manufacturing Inc., Rockwell, North Carolina, United States;3. School of Food Science and Nutrition, Woo Song University, Daejeon, South Korea;4. Department of Environmental Engineering, Hoseo University, Asan, South Korea;1. University of Pittsburgh School of Public Health, Public Health Building, 130 De Soto St, Pittsburgh, PA 15261, USA (Drs Khoudary, Chen, Brooks, and Orchard);2. University of Michigan Department of Epidemiology, 1415 Washington Heights, Ann Arbor, MI 48109, USA (Dr McConnell);3. University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA (Dr Billheimer) |
| Abstract: | Background and aimsArterial stiffness and increased intima-media wall thickness are two of the main predictors of cardiovascular disease (CVD). We evaluated whether brachial-ankle pulse wave velocity (baPWV) and common carotid artery intima-media wall thickness (CCA-IMT) are correlated with alcohol consumption in a cross-sectional study among Korean men and women aged 40 years and over.Methods and resultsAll 5539 subjects (2121 men and 3418 women) were participants in the Multi-Rural Communities cohort (MRcohort) study, a part of the Korean Genome Epidemiology Study (KoGES). The baPWV was positively correlated with alcohol consumption in men (p for trend <0.0001). Age (middle-aged versus elderly) modified the effect of alcohol consumption on PWV. On the other hand CCA-IMT decreased with alcohol consumption in men. There was no favorable zone of alcohol consumption in terms of baPWV and CCA-IMT. Adjustment for lipid profiles substantially attenuated the relationship between alcohol consumption and CCA-IMT. There was no clear relation between alcohol consumption and baPWV/CCA-IMT in women.ConclusionsAlong with a linear harmful relationship between alcohol consumption and arterial stiffness in men there may also be a beneficial relationship between alcohol consumption and carotid intima-wall thickness. The effect of alcohol on arterial stiffness may be slightly stronger in elderly men, and the effect of alcohol on CCA-IMT may be mediated by lipid factors. |
| Keywords: | Alcohol Carotid intima-media thickness Pulse wave velocity Subclinical atherosclerosis Mediator baPWV"} {"#name":"keyword" "$":{"id":"kwrd0040"} "$$":[{"#name":"text" "_":"brachial-ankle pulse wave velocity CCA-IMT"} {"#name":"keyword" "$":{"id":"kwrd0050"} "$$":[{"#name":"text" "_":"common carotid artery intima-media wall thickness |
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