Spontaneous unilateral renal dysplasia in a clinically healthy cynomolgus monkey (Macaca fascicularis) |
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| Affiliation: | 1. Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT, USA;2. Drug Safety Research and Development, Pfizer Worldwide Research & Development, San Diego, CA, USA;1. Research Center for Toxicology, Cancer, and Degenerative Disease, Department of Pathology, Ulin General Hospital, Medical Faculty Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia;2. Research Center for Toxicology, Cancer, and Degenerative Disease, Department of Medical Chemistry & Biochemistry, Medical Faculty Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia;3. Department of Clinical Pathology, Saiful Anwar General Hospital, Faculty of Medicine, University of Brawijaya, Malang, East Java, Indonesia;4. Laboratory of Pharmacology, Faculty of Medicine, University of Brawijaya, Malang, East Java, Indonesia;5. Department of Paediatric, Saiful Anwar General Hospital, Faculty of Medicine, University of Brawijaya, Malang, East Java, Indonesia;1. Genentech Research and Early Development, 1 DNA Way, South San Francisco, CA 94080, USA;2. Shin Nippon Biomedical Laboratories, Ltd., Drug Safety Research Laboratories, 2438 Miyanoura, Kagoshima 891-1394, Japan;3. Covance Preclinical Services GmbH, Kesselfeld 29, 48163 Munster, Germany;1. Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA, USA;2. Department of Radiation Oncology, The University of Iowa, Iowa City, IA, USA;3. Department of Pathology, The University of Iowa, Iowa City, IA, USA;4. Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA, USA;1. Department of Radiology, The No.2 People''s Hospital of Nanning, Nanning 530031, China;2. Department of Radiology, Affiliated Hospital of Guilin Medical University, Guilin 541000, China;3. Department of Ultrasound Diagnosis, The No.2 People''s Hospital of Nanning, Nanning 530031, China;1. Onco-Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan;2. Department of Diagnostic Pathology, Tomakomai City Hospital, Hokkaido 053-8567, Japan |
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| Abstract: | Renal dysplasia is a congenital renal malformation characterized by disruption of normal renal development with asynchronous differentiation of nephrons, collecting ducts, and parenchyma and abnormal patterning of cortical and medullary tissues. The present article describes unilateral renal dysplasia discovered in a cynomolgus monkey from a routine toxicology study. The affected kidney was small and characterized by extensive interstitial fibrosis with the formation of fibromuscular collars around glomeruli and tubules, immature nephrons, and persistent mesenchyme encompassing few collecting ducts. The present case is remarkable in that there is a paucity of reports describing histopathologic findings of spontaneously occurring renal dysplasia in preclinical test species for use in large animal toxicity studies. |
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| Keywords: | Cynomolgus monkey Kidney Dysplasia Histopathology |
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