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PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma |
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| Authors: | Jara Majuelos-Melguizo María Isabel Rodríguez Laura López-Jiménez Jose M. Rodríguez-Vargas Juan M. Martí Martín-Consuegra Santiago Serrano-Sáenz Julie Gavard J Mariano Ruiz de Almodóvar F Javier Oliver |
| Affiliation: | 1. Instituto de Parasitología y Biomedicina López Neyra, CSIC, Granada, Spain;2. IBIMER, Centro de Investigación Biomédica, Universidad de Granada, Spain;3. CNRS, UMR8104, Paris, France |
| Abstract: | |
| Keywords: | BUBR1 Mitotic catastrophe Glioblastoma Homologous recombination PARP1 PTEN genomic instability EGFR |