Retained fetal adrenal cortex in a cynomolgus macaque (Macaca fascicularis) |
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| Affiliation: | 1. Pfizer Worldwide Research and Development, Drug Safety Research and Development, 1 Burtt Road, Andover, MA 01810, USA;2. Pfizer Worldwide Research and Development, Drug Safety Research and Development, 10646 Science Center Drive, San Diego, CA 92121, USA;1. Discipline of Surgery, School of Medicine, The Queen Elizabeth Hospital, University of Adelaide, Woodville, Australia;2. School of Paediatrics and Reproductive Health, University of Adelaide, Australia;3. Research Centre for Reproductive Health, The Robinson Institute, University of Adelaide, Australia;1. Research Center for Toxicology, Cancer, and Degenerative Disease, Department of Pathology, Ulin General Hospital, Medical Faculty Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia;2. Research Center for Toxicology, Cancer, and Degenerative Disease, Department of Medical Chemistry & Biochemistry, Medical Faculty Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia;3. Department of Clinical Pathology, Saiful Anwar General Hospital, Faculty of Medicine, University of Brawijaya, Malang, East Java, Indonesia;4. Laboratory of Pharmacology, Faculty of Medicine, University of Brawijaya, Malang, East Java, Indonesia;5. Department of Paediatric, Saiful Anwar General Hospital, Faculty of Medicine, University of Brawijaya, Malang, East Java, Indonesia;1. Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA, USA;2. Department of Radiation Oncology, The University of Iowa, Iowa City, IA, USA;3. Department of Pathology, The University of Iowa, Iowa City, IA, USA;4. Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA, USA |
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| Abstract: | An incidental, bilateral, retained fetal adrenal cortex was detected in a male cynomolgus macaque (age, approximately 2.4 y) used in a 4-week toxicology study. Microscopic examination of the adrenal gland cortex zone revealed the presence of additional solid sheets and columns of cells supported by vascular capillary bed and composed of large polyhedral cells with abundant eosinophilic, slightly finely vacuolated cytoplasm that surrounded the entire circumference of the medulla. Nuclei were vesicular, round to oval with prominent small nucleoli. There was no evidence for inflammation or cellular degeneration. Based on the microscopic examination, a diagnosis of retained fetal cortex of the adrenal gland was made. This morphologic change resembles fetal cortex in human infants. To our knowledge, this case description is the first report of a cynomolgus macaque with the rare entity of retained fetal cortex, which should not be misinterpreted as a test article-related change. |
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| Keywords: | Adrenal gland Cynomolgus macaque Histopathology Retained adrenal cortex Toxicology |
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