In vitro pharmacodynamics and in vivo efficacy of fluconazole,amphotericin B and caspofungin in a murine infection by Candida lusitaniae |
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| Affiliation: | 1. Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain;2. Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, TX, USA;1. Department of Pharmacology, Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China;2. Pharmacy of Beijing Chest Hospital affiliated to The Capital Medical University, Beijing, China;1. Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto, Japan;2. Department of Anesthesia, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto, Japan;1. Digestive Disease Center, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan;2. Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan;3. Department of Infectious Diseases, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan;1. Physicalchemistry Departmental Section, Faculty of Pharmacy and Food Sciences, University of Barcelona, Spain;2. IN2UB, Av. Joan XXIII sn., 08028 Barcelona, Spain;3. AU-CSIC, Av. Joan XXIII sn., 08028 Barcelona, Spain |
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| Abstract: | The in vitro activities of fluconazole (FLC), amphotericin B (AmB) and caspofungin (CSP) were evaluated against three isolates of Candida lusitaniae using time–kill curves. AmB showed in vitro fungicidal activity, whilst FLC and CSP exerted mainly strain-dependent fungistatic activity. The in vivo efficacies of the three drugs were evaluated in a murine model of disseminated infection. The doses administered were FLC 50 mg/kg/day, AmB 0.8 mg/kg/day and CSP 5 mg/kg/day. All three drugs were able to reduce the fungal burden in the kidneys of infected mice, with AmB showing the highest efficacy, followed by CSP. At least in this model, FLC, AmB and CSP are good candidates for treating invasive infections by C. lusitaniae. |
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| Keywords: | Animal model Murine Fungal infection Antifungal therapy |
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