Association between irritable bowel syndrome and colorectal cancer: A nationwide population-based study |
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| Institution: | 1. Division of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;2. Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;3. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan;4. Division of Colorectal Surgery, Department of Surgery, China Medical University Hospital, Taichung, Taiwan;5. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan;6. Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan;7. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan;8. Department of Public Health, China Medical University and Hospital, Taichung, Taiwan;1. Department of Neurology, Zhongshan Hospital, Fudan University, 200032 Shanghai, China;2. Institute of Brain Science and State Key laboratory of Medical Neurobiology, Fudan University, 200032 Shanghai, China;1. University College Cork Medical School, Brookfield College of Health Sciences, College Rd, Cork, Ireland;2. ASSERT Simulation Centre, University College Cork Medical School, Brookfield College of Health Sciences, College Rd, Cork, Ireland;3. University College Cork Department of General Practice, Western Gate Building, Western Road, Cork, Ireland |
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| Abstract: | ObjectivesTo determine whether irritable bowel syndrome (IBS) is associated with an increased risk for the subsequent colorectal cancer (CRC).MethodsWe identified 91,746 patients who were diagnosed with IBS between 2000 and 2010 from the Taiwan National Health Insurance Research Database (NHIRD) as the study cohort, and randomly extracted the data of 183,492 patients matched by sex, age, and baseline year for the comparison cohort. The follow-up period was terminated after CRC development, withdrawal from the national health insurance (NHI) system, or at the end of 2010. Cumulative incidences and hazard ratios (HRs) of CRC development were determined.ResultsDuring the first 2 years of follow-up, the subsequent CRC incidence rates in the IBS and comparison cohorts were 37.3 and 5.61 per 10,000 person-years, respectively (adjusted HR, 6.72; 95% CI, 5.70–7.92; p < .0001). Thereafter, the risk did not differ significantly between the 2 cohorts (adjusted HR, 1.08; 95% CI, 0.93–1.26); the participants in the IBS cohort commonly underwent more colonoscopies/sigmoidoscopies than did the non-IBS cohort.ConclusionsIBS was not associated with the long-term development of CRC in Taiwan. The increased risk of CRC in the first 2 years may have occurred because some CRC patients were initially misclassified as IBS patients. |
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