The serotonin transporter 5-HTTLPR polymorphism in the association between sleep quality and affect |
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Affiliation: | 1. Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada;2. Golestan University of Medical Sciences, Faculty of Nursing & Midwifery, Gorgan, Islamic Republic of Iran;3. Department of Anatomy, Biology and Molecular Research Center, Babol University of Medical Sciences, Babol, Islamic Republic of Iran;4. Avicenna Institute of Neuroscience, Department of Behavioural Studies, Yazd, Islamic Republic of Iran;5. Golestan University of Medical Sciences, Department of Anatomy, Gorgan, Islamic Republic of Iran |
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Abstract: | A link between sleep and affect is well-known. Serotonin (5-HT) is associated with the regulation of affective as well as sleep-related processes. A functional polymorphism in the serotonin transporter gene (5-HTTLPR) has been associated with serotonergic functioning. The present study investigated whether allelic variation of this gene moderates the association between nighttime subjective sleep quality and affect the following day. A population-based sample of 361 ethnically homogenous adult female twins underwent a five day protocol based on the experience sampling method (ESM), assessing momentary negative affect, positive affect, and subjective sleep quality repeatedly and prospectively. There was a significant interaction between sleep quality and genotype in predicting positive affect the next day: carriers of one (n=167) or two S-alleles (n=78) had a significantly steeper slope compared to LL carriers (n=116) (χ2=4.16, p=.042 and χ2=3.90, p=.048 respectively). The association between subjective sleep quality and positive affect the next day varied as a function of 5-HTTLPR: it was stronger in carriers of at least one copy of the S-allele compared to homozygous L-carriers, supporting a link between sleep and affect regulation, in which serotonin may play a role. However, these results are preliminary and require replication. |
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Keywords: | 5-HTTLPR Subjective sleep quality Positive affect Negative affect Experience sampling method Daily life |
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