Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness,insulin resistance and nonalcoholic fatty liver disease in children and adolescents |
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| Affiliation: | 1. Department of Pediatrics and Child Neuropsychiatry, Sapienza University of Rome, Italy;2. Department of Experimental Medicine, Sapienza University of Rome, Italy;3. Department of Radiological Sciences, Sapienza University of Rome, Italy;4. Institute of Translational Pharmacology, National Research Council, Via del Fosso del Cavaliere 100, 00133 Rome, Italy;1. Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran;2. Razi Herbal Medicines Research Center, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran;1. Department of Bariatric Surgery, GEM Hospital and Research Centre, Tamil Nadu, India;2. Department of Hepatology, GEM Hospital and Research Centre, Tamil Nadu, India;3. Department of Pathology, GEM Hospital and Research Centre, Tamil Nadu, India;2. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom;3. Institute for Infection and Immunity, St George''s University of London, London, United Kingdom;4. St George''s University Hospitals NHS Foundation Trust, London, United Kingdom;6. Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany;5. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany;1. Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics and the Digestive Health Institute, Children''s Hospital Colorado and University of Colorado School of Medicine, Aurora, CO;2. Department of Pathology, Children''s Hospital Colorado and University of Colorado School of Medicine, Aurora, CO;3. Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO;4. Pulmonary Section, Department of Pediatrics, Children''s Hospital Colorado and University of Colorado School of Medicine, Aurora, CO |
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| Abstract: | Background and aimsThe triglyceride (TG)/high-density lipoprotein-cholesterol (HDL-C) ratio has been reported as a useful marker of atherogenic lipid abnormalities, insulin resistance, and cardiovascular disease. We evaluated in a large sample of children and adolescents the association of TG/HDL-C ratio with early signs of morphological vascular changes and cardiometabolic risk factors including nonalcoholic fatty liver disease (NAFLD).Methods and resultsThe study population, including 548 children (aged 6–16 years), of whom 157 were normal-weight, 118 overweight, and 273 obese, had anthropometric, laboratory, liver and carotid ultrasonography (carotid artery intima-media thickness-cIMT) data collected. Subjects were stratified into tertiles of TG/HDL-C. There was a progressive increase in body mass index (BMI), BMI-SD score (SDS), waist circumference, blood pressure (BP), liver enzymes, glucose, insulin, homeostasis model assessment of insulin resistance, high-sensitivity C-reactive protein (hsCRP), and cIMT values across TG/HDL-C tertiles. The odds ratios for central obesity, insulin resistance, high hsCRP, NAFLD, metabolic syndrome, and elevated cIMT increased significantly with the increasing tertile of TG/HDL-C ratio, after adjustment for age, gender, pubertal status, and BMI-SDS. In a stepwise multivariate logistic regression analysis, increased cIMT was associated with high TG/HDL-C ratio [OR, 1.81 (95% CI, 1.08–3.04); P < 0.05], elevated BP [5.13 (95% CI, 1.03–15.08); P < 0.05], insulin resistance [2.16 (95% CI, 1.30–3.39); P < 0.01], and NAFLD [2.70 (95% CI, 1.62–4.56); P < 0.01].ConclusionTG/HDL-C ratio may help identify children and adolescents at high risk for structural vascular changes and metabolic derangement. |
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| Keywords: | Triglyceride-to-HDL cholesterol ratio Carotid artery intima-media thickness Insulin resistance Nonalcoholic fatty liver disease Children |
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