Abnormal cingulum bundle development in autism: A probabilistic tractography study |
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| Affiliation: | 1. Aging, Mobility, and Cognitive Neuroscience Laboratory, Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada;2. Brain Research Centre, University of British Columbia, Vancouver, BC, Canada;3. Experimental Medicine Graduate Program, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada;4. Geriatric Psychiatry Neuroimaging Laboratory, Faculty of Medicine, University of Pittsburgh, Pittsburgh, PA, USA;5. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA;6. Department of Psychiatry, University of California, San Francisco, CA, USA;7. Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA;8. Center for Aging and Population Health, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA;2. Division of Cardiology, Department of Medicine, Mount Sinai Medical Center, Miami Beach, Florida;3. Departments of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, Georgia;4. Department of Neurology, Medical College of Georgia, Augusta University, Augusta, Georgia;1. Department of Pediatrics, Cincinnati Children''s Hospital Medical Center, 3333 Burnet Ave, MLC 7039, Cincinnati, OH 45229-3039, United States of America;2. University of Cincinnati College of Medicine, United States of America;3. Department of Radiology, Cincinnati Children''s Hospital Medical Center, 3333 Burnet Ave, MLC 7039, Cincinnati, OH 45229-3039, United States of America;1. Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA, United States;2. Department of Psychiatry, Boston Children''s Hospital, Harvard Medical School, Boston, MA, United States;3. Department of General Psychiatry, Medical University Innsbruck, Innsbruck, Austria;4. Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center, Public Psychiatry Division, Harvard Medical School, Boston, MA, United States;5. Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States;6. Department of Medicine, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA, United States;7. Stanley Center of Psychiatry Research, Broad Institute of MIT and Harvard, Boston, MA, United States;8. Psychiatry and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, United States;9. Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA, United States |
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| Abstract: | There is now considerable evidence that white matter abnormalities play a role in the neurobiology of autism. Little research has been directed, however, at understanding (a) typical white matter development in autism and how this relates to neurocognitive impairments observed in the disorder. In this study we used probabilistic tractography to identify the cingulum bundle in 21 adolescents and young adults with Autism Spectrum Disorder (ASD), and 21 age- and sex-matched healthy volunteers. We investigated group differences in the relationships between age and fractional anisotropy, a putative measure of white matter integrity, within the cingulum bundle. Moreover, in a preliminary investigation, we examined the relationship between cingulum fractional anisotropy and executive functioning using the Behavior Rating Inventory of Executive Function (BRIEF). The ASD participants demonstrated significantly lower fractional anisotropy within the cingulum bundle compared to the typically developing volunteers. There was a significant group-by-age interaction such that the ASD group did not show the typical age-associated increases in fractional anisotropy observed among healthy individuals. Moreover, lower fractional anisotropy within the cingulum bundle was associated with worse BRIEF behavioral regulation index scores in the ASD group. The current findings implicate a dysregulation in cingulum bundle white matter development occurring in late adolescence and early adulthood in ASD, and suggest that greater disturbances in this trajectory are associated with executive dysfunction in ASD. |
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| Keywords: | Autism spectrum disorder Diffusion tensor imaging White matter Development |
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