Peripheral T cell lymphoma,not otherwise specified with myelofibrosis: report of a case with review of the literature |
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Authors: | Yasunobu Sekiguchi Syuichi Shirane Asami Shimada Kunimoto Ichikawa Mutsumi Wakabayashi Keiji Sugimoto Shigeki Tomita Hiroshi Izumi Noriko Nakamura Tomohiro Sawada Yasunori Ohta Norio Komatsu Masaaki Noguchi |
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Affiliation: | 1.Department of Hematology, Juntendo University Urayasu Hospital, Japan;2.Department of Hematology, Juntendo University Hospital, Japan;3.Department of Pathology, Juntendo University Urayasu Hospital, Japan;4.Department of Clinical Laboratory, Juntendo University Urayasu Hospital, Japan;5.Department of Pathology, Research Hospital, Institute of Medical Science, University of Tokyo, Japan |
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Abstract: | A 68-year-old man presented to us with pancytopenia, erythroderma, and multiple lymphadenopathies. Lymph node biopsy led to the diagnosis of peripheral T-Cell lymphoma-not otherwise specified (PTCL-NOS). Immunostaining of the lymph node biopsy specimens for cytokines revealed that the tumor cells were positive for plated-derived growth factor (PDGF), basic fibroblast growth factor (b-FGF), vascular endothelial growth factor (VEGF), tumor necrosis factor α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), interleukin-2 (IL-2), and transforming growth factor-β (TGF-β). Bone marrow biopsy revealed infiltration by the PTCL-NOS and myelofibrosis (MF). Bone marrow blood was negative for JAK-2V617F. Bone marrow immunostaining for cytokines showed that the tumor cells were positive for PDGF, b-FGF, VEGF, TNF-α, IFN-γ, IL-1β, IL-2, and TGF-β. The patient was initiated on treatment, and after the first course of CHOP therapy, the bone marrow infiltration by the PTCL-NOS and MF improved. Repeat immunostaining of bone marrow biopsy specimens for cytokines showed that the tumor cells had become negative for PDGF, VEGF, TNF-α and TGF-β. However, after the second course of CHOP therapy, the bone marrow infiltration by the PTCL-NOS and MF worsened. Immunostaining of bone marrow specimens for cytokines again revealed positive staining results of the tumor cells for PDGF, TNF-α, and TGF-β. At the completion of the first course of treatment, the infiltration by the PTCL-NOS improved, but not the pancytopenia. |
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Keywords: | Peripheral T-Cell lymphoma-not otherwise specified (PTCL-NOS), bone marrow fibrosis (MF), platelet-derived growth factor (PDGF), tumor necrosis factor α (TNFα ), transforming growth factor-β (TGF-β ) |
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