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| 睫状神经营养因子对损伤脊髓神经元酶学的影响 | |
| 引用本文： | 许斌,吴宏,贾连顺,李家顺. 睫状神经营养因子对损伤脊髓神经元酶学的影响[J]. 医学研究生学报, 2001, 14(2): 132-134 |
| 作者姓名： | 许斌 吴宏 贾连顺 李家顺 |
| 作者单位： | 1. 南京军区南京总医院骨科 2. 福建省立医院骨科 3. 第二军医大学长征医院骨科 |
| 摘 要： | 目的：研究脊髓损伤后脊髓神经元的酶学变化，并探索睫状神经营养因子（CNTF）对脊髓神经元的保护作用。方法：用改良Allen打击法致SD大鼠T8脊髓损伤，分别于术术前术后第3、7、14天测定脊髓组织内乙酰胆碱酯酶（AChE)和酸性磷酸酶（ACP）的含量。结果：AChE于手术持续下降，ACP在术后3天开始上升，第7天升至最高，以后逐渐下降，经CNTF治疗后上述峡谷种酶变化的幅度较小，且整个过程比较平衡，结论：CNTF对脊髓损伤的神经元具有一定的保护作用。 |
| 关 键 词： | 脊髓损伤 睫状神经营养因子 神经元 酶 |
| 文章编号： | 1008-8199(2001)02-0132-03 |
| 修稿时间： | 2000-09-18 |
Protective effect of ciliary neurotrophic factor on spinal neurons |
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| XU Bin,WU Hong,JIA Lian-shun,LI Jia-shun. Protective effect of ciliary neurotrophic factor on spinal neurons[J]. Bulletin of Medical Postgraduate, 2001, 14(2): 132-134 | |
| Authors: | XU Bin WU Hong JIA Lian-shun LI Jia-shun |
| Affiliation: | XU Bin1,WU Hong2,JIA Lian shun3,LI Jia shun3 |
| Abstract: | Objectives:To study the enzymatic changes and protective effects of ciliary neurotrophic factor (CNTF) on neurons in spinal cord injury (SCI). Methods: SD rats were subjected to incomplete SCI with modified Allen methods. Activities of acetylcholinesterase (AChE) and acid phosphatase (ACP) in spinal cord were quantitatively measured preoperatively, and 3, 7, 14 days after SCI. Results:AChE activity decreased gradually after injury. ACP activity increased 3 days after injury, and reached peak on the 7th day, then recovered gradually. The rats treated with CNTF showed relatively smooth change of the 2 kinds of enzymes. Conclusions:CNTF plays a role in protecting the spinal cord neurons against injury. |
| Keywords: | Spinal cord injury Ciliary neurotrophic factor Neurons Enzymes |
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