首页 | 本学科首页   官方微博 | 高级检索  
     

绞股蓝皂苷对家兔肠缺血再灌注致心肌损伤的保护作用
引用本文:葛君,朱妤婕,吴军,姚蓓蓓. 绞股蓝皂苷对家兔肠缺血再灌注致心肌损伤的保护作用[J]. 蚌埠医学院学报, 2006, 31(4): 347-348
作者姓名:葛君  朱妤婕  吴军  姚蓓蓓
作者单位:蚌埠医学院临床医学系2002年级, 安徽蚌埠 233030
基金项目:本实验承蒙关宿东和杨丽娟两位老师指导,谨此致谢
摘    要:目的: 观察绞股蓝皂苷对家兔肠缺血再灌注引起的心肌损伤的影响。方法: 取成年家兔12只,随机分为2组。对照组:静脉注射同绞股蓝皂苷组等量的生理盐水;绞股蓝皂苷组:静脉注射1%绞股蓝皂苷2 ml·kg-1·d-1。每天1次,连续3天,第4天家兔麻醉后,夹闭肠系膜上动脉复制肠缺血再灌注心肌损伤模型。记录家兔夹闭前及夹闭1 h后再灌注2 h的心室内压,利用Medlab-U/4c生物信号采集处理系统采集并分析。结果: 夹闭前,对照组与绞股蓝皂苷组左心室收缩峰压(LVSP)、室内压最大上升(下降)速率(±dp/dtmax)、室内压最大值(Vpm)均无明显不同(P>0.05)。夹闭1 h后再灌注2 h,与对照组比较,绞股蓝皂苷组LVSP、+dp/dtmax、Vpm均显著升高(P<0.01),-dp/dtmax明显降低(P<0.01)。结论: 肠缺血再灌注对心肌有损伤作用,绞股蓝皂苷可明显改善心肌的收缩功能,对损伤的心肌有保护作用。

关 键 词:心脏/生理学   心肌再灌注损伤   缺血再灌注   绞股蓝皂苷  
文章编号:1000-2200(2006)04-0347-02
收稿时间:2005-11-24
修稿时间:2005-11-24

Protective effects of gypenosides on the heart injury after intestinal ischemia-reperfusion in rabbits
GE Jun,ZHU Yu-jie,WU Jun,YAO Bei-bei. Protective effects of gypenosides on the heart injury after intestinal ischemia-reperfusion in rabbits[J]. Journal of Bengbu Medical College, 2006, 31(4): 347-348
Authors:GE Jun  ZHU Yu-jie  WU Jun  YAO Bei-bei
Affiliation:Faculty of Clinical Medicine. Bengbu Medical College. Bengbu 233030, China
Abstract:Objective: This study was designed to characterize the ultrastructure of the coccoid Helicobacter pylori(H. pylori) forms in the tissues of carcinoma.Methods: Transmission electron microscopy(TEM) technique was used to examine the structure of coccoid H. pylori in 4 cases of gastric carcinoma and 2 cases of esophageal carcinoma.Results: It was found that the coccoid H. pylori were scattered in cancer nest and cancer interspace,some of which enterded cancer cells,macrophages and other cells.The coccoid H. pylori appeared to be similar to the L-forms of other bacteria with varying cell shape and size,different cytoplasmic electron densities and defects in cell wall.Two types of coccoid H. pylori could be distinguished in the tissues of carcinoma by TEM.Type A was smaller with higher electron density in the cytoplasma,and flagellation on the cell membrane,suggesting that it could be viable.However,the type B was larger with lower electron density in the cytoplasma,and no flagellation on the cell membrane,suggesting that it could be a degenerative form.Conclusions: The coccoid forms of H.pulori still have certain degree of viability,thus they may play an important role in the transmission of H. pylori,the relapse of H. pylori related disease after treatment and the development of the related carcinoma.
Keywords:heart/physiology    ischemia-reperfuion    gypenosides    rabbits
本文献已被 CNKI 万方数据 等数据库收录!
点击此处可从《蚌埠医学院学报》浏览原始摘要信息
点击此处可从《蚌埠医学院学报》下载全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号