Functional evaluation of polyarylamide fibers for use in a prosthesis for anterior cruciate ligament replacement in the sheep |
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| Authors: | Therin M Christel P Crespeau F Dürselen L Claes L |
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| Affiliation: | 1. Service de Chirurgie Orthopédique et Traumatologique, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75010 Paris, France;2. Laboratoire d''Anatomopathologie, Ecole Nationale Vétérinaire, Maisons Alfort, France;3. Biomechanics Laboratory, Ulm University, Germany;1. School of Mechanical and Electrical Engineering, China University of Mining and Technology, Xuzhou 221116, Jiangsu Province, China;2. Jiangsu Key Laboratory of Mine Mechanical and Electrical Equipment, China University of Mining & Technology, Xuzhou 221116, Jiangsu Province, China;3. Jiangsu Collaborative Innovation Center of Intelligent Mining Equipment, Xuzhou 221008, China;4. College of Mechanical Engineering, Chongqing University, Chongqing 400044, China;5. CITIC Heavy Industries Co. Ltd, Luoyang 471039, Henan Province, China;6. Luoyang Mining Machinery Engineering Design Institute, Luoyang 471039, Henan Province, China;1. College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China;2. Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan, China;3. Key Laboratory of Urban Agriculture in Central China, Ministry of Agriculture and Rural Affairs, China;4. Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria;5. College of Food Science and Engineering, Shanxi Agricultural University, Jinzhong, China;1. Centre for Blood Research and Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada;2. Department of Materials Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada;3. School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada;4. Department of Mechanical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;5. Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada;1. CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China;2. Guangdong-Hong Kong-Macao Joint Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China;3. Department of Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong 999077, China;4. National Synchrotron Radiation Laboratory, Chinese Academy of Sciences Key Laboratory of Soft Matter Chemistry, and Anhui Provincial Engineering Laboratory of Advanced Functional Polymer Film, University of Science and Technology of China, Hefei 230026, China |
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| Abstract: | In order to evaluate the potential use of polyarylamide fibers as a prosthetic material for ligament replacement, resected sheep anterior cruciate ligaments were replaced by braided devices routed through a tibial tunnel and over the top of the lateral femoral condyle. Twelve sheep were used and sacrificed between 3 and 12 months. The tissue response to the implant was evaluated histologically. Morphologic features of the fibers and the abraded particles were measured by image analysis. Simultaneously, the tensile properties as well as the creep and fatigue properties of non-implanted prostheses were measured under laboratory conditions. It was shown that the polyarylamide fibers exhibited high strength, a high modulus, but low fatigue abrasion properties. At autopsy, 1 prosthesis was broken, 6 had frayed and 5 were intact. There was no adverse tissue response to the intact fibers. Inflammation was always linked to the presence of polymeric particles. A large bony ingrowth in the tibial tunnel through the prostheses strands was observed. There was no material resorption throughout the experiment. Polyarylamide fibers appear to be a suitable material for ligament replacement provided that abrasion against bone can be avoided. |
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