抗痫煎剂治疗特发性全身性强直-阵挛发作型癫痫的临床研究

目的:观察抗痫煎剂对特发性全身性强直-阵挛发作型癫痫的临床疗效、中医辨证分型的疗效差异以及脑电图的改变。方法:对照组:特发性全身性强直-阵挛发作性癫痫口服丙戊酸钠片0.2g次/,3次/日,不能控制者可加量至0.4g次/,3次/日;治疗组:全部患者均在按对照组用药基础上加用抗痫煎剂,两组均连用3个月为1个疗程,1个疗程后进行疗效评定。结果:两组总有效率比较,有显著性差异(P<0.05),治疗组优于对照组;同一证型治疗组与对照组有效率比较,风痰闭阻型非常有显著差异(P<0.01),痰火扰神,有显著性差异(P<0.05),血虚生风,心脾两虚,肝肾阴虚均无显著性差异。在改善脑电图方面治疗组亦优于对照组。结论:抗痫煎剂对特发性全身性强直-阵挛发作型癫痫有较好的抗痫作用,以风痰闭阻、痰火扰神尤佳,对脑电图的改善亦优于对照组。

Study on the treatment by using Anti-epilepsy decoction for idiopathic epilepsy with generalized tonic-clonic seizures

Objective:To Observe the clinical effect and differentiation of symptom and EEG changes by using anti-epileptic decoction for idiopathic epilepsy with generalized tonic-clonic seizures.Methods:The control group: Idiopathic epilepsy with generalized tonic-clonic seizures(0.2g/each,tid),epilepsy which can not control(0.4g/each,tid);The treatment group: On the basis of drug in the control group,all patients were used anti-epileptic decoction,both groups were Continuly used of three months for a course,and then for Clinical Evaluationt.Results:The total effective rate are a significant difference in the treatment group and the control group(P<0.05),the wind phlegm obstacle orifice syndrome are obviously significant differences(P<0.01),the pyrophlegm intervene mind are significant differences(P<0.05),between the treatment group and the control group in the same syndromes,the effective rate of the deficiency of blood with production of wind,heart-spleen deficiency,hepatic and renal yin deficiency are not significant differences,the treatment group are superior to the control group considering that it can improve the results of EEG.Conclusion:Anti-epilepsy decoction had an effective treatment on idiopathic epilepsy with generalized tonic-clonic seizures.the wind phlegm obstacle orifice syndrome and the pyrophlegm intervene mind were particularly good,and superior to the control group for improve the results of EEG.