Jordans' Anomaly in White Blood Cells: Report of Case

Persistent vacuoles were seen in the protoplasm of granulocytes, monocytesand occasional lymphocytes of 2 sisters suffering from ichthyosis. In the bonemarrow these vacuoles were found in the cytoplasm of promyelocytes, myelocytes, metamyelocytes and rarely in plasma cells. They were not observed inblasts or in red cells and thrombocytes and their precursors.

With the help of cytochemical staining technics and fluorescence microscopystudies, it was determined that the vacuoles contained lipids. A similar abnormality of leukocytes was described previously by Jordans in 2 brothers suffering from muscular dystrophy.

Ichthyosis was transmitted in this family in an autosomal recessive way.

Submitted on September 14, 1965 Accepted on December 10, 1965