卡维地洛和美托洛尔对慢性充血性心力衰竭患者左心室及血管内皮舒张功能的影响

目的探讨卡维地洛和美托洛尔对慢性充血性心力衰竭（CHF）患者左心室及血管舒张功能的影响。方法76例CHF患者随机分为两组，每组38例，在常规治疗基础上分别采用卡维地洛和关托洛尔，检测两组的左心室及血管舒张功能。结果两组治疗后E峰、A峰及E／A都较治疗前都有明显改善，差异有统计学意义（P〈0．05）。卡维地洛组治疗后E峰、A峰及E／A改善状况较美托洛尔组明显，差异有统计学意义（P〈0．05）。卡维地洛组治疗后D1、D2、△1和△2都明显高于治疗前水平，差异有统计学意义（P〈0．05）。卡雄地洛组治疗后D1、D2、△1和△2值明显高于美托洛尔组治疗后水平，差异有统计学意义（P〈0．05）。结论非选择性受体阻滞剂卡维地洛在改善左心和血管舒张功能方面显著优于选择性β1受体阻滞剂美托洛尔，在CHF的临床治疗中具有重要作用。

Effects of Metoprolol and Carvedilol on Left Ventricle and Vascular Endothelial Diastolic Function in Patients with Chronic Heart Failure

OBJECTIVE To explore the effects of metoprolol and carvedilol on left ventricle and vascular endothelial diastolic function in patients with chronic heart failure. METHODS 76 cares CHF patients were randomly classified into two groups, which were treated with metoprolol and carvedlol, respectively. All patients＇ left ventricle and vascular endothelial diastolic function were examined. RESULTS After treatment, the levels of E, A and E/A in two groups were significantly improved（P〈0.05）. After treatment, the levels of E, A and E/A in carvedilol group were significantly imiroved than those in metoprolol group（P〈0.05）. After treatment, the levels of E, A and E/A in arvedilol group were significantly improved than those in metoprolol group（P〈0.05）. In carvedilol group, the value of D1, D2, △1, △2in post-treatment were significantly higher than those in pretreatment（P〈0.05）. After treatment, the value of Dl, D2, △1, △2 in carvedilol group were significantly improved than those in metoprolol group（P〈0.05）. CONCLUSION Carvedilol in improving left ventricle and vascular endothelial diastolic function is better than metoprolol, whieh plays an important rule in treatment with CHF.