Relationship between remodeling and function of left ventricle and angiotensin Ⅱ AT1 receptor expression after myocardial infarction in rats

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Relationship between remodeling and function of left vent ricle and angiotensin AT1 receptor expression after myocardial infarction in rats

Objective To determine the relationship between remodeling and dysfunct ion of left ventricle (LV) and the expression of the angiotensin AT1 receptor mRNA after myocardial infarction (MI) in rats Methods Nine MI rats (Group A) and 8 shamoperated rats (Group B) were studied by both Doppler echocardiography and Dot blot using Digoxingeninlabel led cDNA probes Results Compared with Group B, Group A showed the increase in LV intern al diastolic diameter (087006?mm vs 066003?mm, respectively, P <001) and volume (073009?ml vs 051005?ml, P < 0 01) In addition, thinning of anterior wall, thickening of posterior wall, in cr easing of peak early filling velocity (peak E), decreasing of late filling veloc ity (peak A) and increasing of the E/A were demonstrated in MI rats 7 weeks aft er MI The levels of the cardiac angiotensin AT1 receptor mRNA in Group A we re higher than those of Group B (22fold) Conclusions Seven weeks after MI in rats, character of LV remodeling an d dysfunction were developed and the expression of cardiac angiotensin AT1 re ceptor mRNA was increased