How Is the Liver Primed or Sensitized for Alcoholic Liver Disease? |
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| Institution: | USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases (HT, ML, MO, KM, NK), Los Angeles, California;the Department of Gastroenterology (YT, NE, KI, TK, HO, MH, HK, SY, AK, MI, HS, NS), Juntendo University, Tokyo, Japan;the Department of Internal Medicine (CJM, SJ-B, DH, JS, ID, SB, RKC, SB, WW, WN), University of Kentucky Medical Center and Lexington VA Hospital, Lexington, Kentucky;Liver Unit IDIBAPS (AC, CG-R, NK, JCF-C), CSIC, Barcelona, Spain;the Department of Internal Medicine (HY, YO, YN, NF), School of Medicine, Keio University, Tokyo, Japan;and the Laboratory of Hepatobiology and Toxicology, Department of Pharmacology (BUB, CAR, SP, RT), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. |
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| Abstract: | This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Hidekazu Tsukamoto and Yoshiyuki Takei. The presentations were (1) Tribute to Professor Rajendar K. Chawla, by Craig J. McClain; (2) Dysregulated TNF signaling in alcoholic liver disease, by Craig J. McClain, S. Joshi-Barve, D. Hill, J Schmidt, I. Deaciuc, and S. Barve; (3) The role of mitochondria in ethanol-mediated sensitization of the liver, by Anna Colell, Carmen Garcia-Ruiz, Neil Kaplowitz, and Jose C. Fernandez-Checa; (4) A peroxisome proliferator (bezafibrate) can prevent superoxide anion release into hepatic sinusoid after acute ethanol administration, by Hirokazu Yokoyama, Yukishige Okamura, Yuji Nakamura, and Hiromasa Ishii; (5) S-adenosylmethionine affects tumor necrosis factor-α gene expression in macrophages, by Rajendar K. Chawla, S. Barve, S. Joshi-Barve, W. Watson, W. Nelson, and C. McClain; (6) Iron, retinoic acid and hepatic macrophage TNFα gene expression in ALD, by Hidekazu Tsukamoto, Min Lin, Mitsuru Ohata, and Kenta Motomura; and (7) Role of Kupffer cells and gut-derived endotoxin in alcoholic liver injury, by N. Enomoto, K. Ikejima, T. Kitamura, H. Oide, Y. Takei, M. Hirose, B. U. Bradford, C. A. Rivera, H. Kono, S. Peter, S. Yamashina, A. Konno, M. Ishikawa, H. Shimizu, N. Sato, and R. Thurman. |
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| Keywords: | Tumor Necrosis Factor Mitochondria Peroxisome Proliferator S-Adenosylmethionine Iron Hepatic Macrophages |
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