小鼠高碘甲状腺肿的实验研究

目的 :为了解小鼠高碘甲状腺肿的发病机理。方法 :实验分 4个组。对照组 (A) ,小鼠饮水含碘量为 10 .8μg/L ,实验组 (B、C和D)小鼠饮水含碘量分别为 5 0 0 0 μg/L、10 0 0 0 μg/L、2 0 0 0 0 μg/L。实验时间为 15 0d。观察甲状腺组织形态学、甲状腺组织碘含量、甲状腺过氧化酶 (TPO)活性及血清TSH和甲状腺激素浓度的改变。结果 :实验各组甲状腺组碘含量、血清FT4水平明显高于对照组 ,且随摄入碘量的增加而增加。实验各级TPO活性、C组和D组血清FT3 水平明显低于照组。实验各组甲状腺呈典型的胶质性甲状腺肿。高碘对小鼠甲状腺形态与功能具有抑制作用。结论 :高碘甲状腺肿是由于滤泡扩张 ,过多胶质堆积在滤胞腔内所致 ,并非TSH升高导致甲状腺滤泡增生的结果 ,高碘对甲状腺有损害

Experimental study for the effect of mice's thyrocele caused by different excess iodide

Objective: The experiment was designed to study pathogenesis of iodide goiter by performing in morphological observation and measuring thyroid function.Methods: The mice of experimental groups( group B,C and D) were raised with high iodine water containing iodine 5000, 10000 and 20000 ug per liter respectively. The mice of control group (group A)were drunk10.8μg/L water. After 150 days, the mice were killed and studied for morphology of thyroid tissue, thyroid iodine contents, thyroid concentrations, peroxidase(TPO)activity and serum thyroid hormone and TSH Results: The results showed thyroid iodine contents and FT 4 levels of three experimental groups increased with increasing in take of iodide, and were higher than those of the control group, while the TPO activity of three experimental groups and FT 4 levels of group C and D was lower than that of the control group. The thyroid in three experimental groups was typical colloid goiter. Conclusion: Excess iodine has inhibitory effects on thyroid morphology and function, and iodide goiter is due to excess iodine to form excess thyrocolloid stored in expansive follicular lumens. Iodide goiter is not due to elevation of TSH level to induce the thyroid follicular hyperplasia, so excess iodine can damage the thyroid.