甲状腺自身抗体联合检测在Graves病和桥本氏甲状腺炎中的诊断意义

目的探讨抗甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)和促甲状腺激素受体抗体(TRAb)在Graves病和桥本氏甲状腺炎中的诊断意义。方法对我院在2006-2009年收治的264例Graves病患者和86例桥本氏甲状腺炎患者,分别检测血中TGAb,TPOAb和TRAb的含量,观察两组间的差异,并对264例Graves病患者根据病情分为初治组、治疗组和缓解组,同样检测血中以上3种抗体,观察其在病程中的动态变化。结果 TRAb在Graves病患者中阳性率较高,并随病情的缓解,浓度逐渐下降,因此,TRAb可作为Graves病的诊断依据,并同时可作为检测病情变化的一项重要指标。结论 TGAb和TPOAb,特别是TPOAb,在桥本氏甲状腺炎患者中阳性率较高,具有统计学意义,故可作为该疾病的诊断依据。

The Importance of Measuring Thyroid auto-antibodies on Graves' disease and Hashimotos thyroiditis Diagnosis

Objective We did this research to discuss the clinical importance of measuring serum thyroglobulin antibody（TGAb）,thyroid peroxydase antibody（TPOAb）,and TSH receptors antibody（TRAb） on Graves＇ disease and Hashimotos thyroiditis diagnosis.Methods We chose 264 Graves＇ disease patients and 86 Hashimotos thyroiditis patients,measured serum TGAb,TPOAb and TRAb separately,compared the concentration of the three kinds of auto-antibodies in the two groups.While we also put 264 Graves＇ disease patients into three groups according to the clinical process,which were named pre-treat group,in-treat group and after-treat group,test the three auto-antibodies,observed the changing in the course of the disease.Results TRAb had high positive rate in Graves＇ disease patients,and its levels got down with the syndrome releasing,therefore TRAbs＇ levels can not only be used as the clinical evidence to Graves＇ disease diagnosis,but also as a marker of disease activity,to aid prediction of the disease course.Conclusion TGAb and TPOAb,especially TPOAb,had high positive rate in Hashimotos thyroiditis patients significantly,thus can be considered as the important evidence to support the diagnosis.