| Affiliation: | (1) Department of Hematology, University of Crete School of Medicine, University Hospital of Heraklion, P.O.Box 1352, Crete, Greece;(2) Department of Gastroenterology, University of Crete School of Medicine, University Hospital of Heraklion, P.O.Box 1352, Crete, Greece;(3) Department of Pathology, University of Crete School of Medicine, University Hospital of Heraklion, P.O.Box 1352, Crete, Greece |
| Abstract: | We describe the first case of a primary gastric plasmacytoma stage I completely regressed following Helicobacter pylori (H.pylori) eradication. The patient, a 61-year-old man, had a long history of chronic gastritis and gastric ulcers with recurrent gastrointestinal hemorrhage. Diagnosis of H.pylori infection was based on the positive urease breath test, the elevated titers of serum anti-H.pylori antibodies, and the detection of the bacterium in gastric mucosa biopsy specimens. Diagnosis of gastric plasmacytoma was based on the findings of histopathology, immunocytochemistry and in situ hybridization. Eradication of H.pylori with antibiotics was followed by disappearance of endoscopic and histopathologic features of the gastric tumor 3 months after the completion of the treatment. No relapse has been documented 20 months after the initial diagnosis of plasmacytoma. A possible causal relationship between the tumor and the underlying H.pylori infection is discussed. |
