食管鳞癌组织中β1整合素的表达及其与生物学行为的关系

目的检测β1整合素在食管鳞癌中的表达,探讨其与食管鳞癌临床生物学行为的关系,为食管鳞癌的基因治疗和预后判断提供理论依据。方法采用S-P免疫组织化学染色法检测10例正常食管粘膜和60例食管鳞癌组织中β1整合素的表达。结果β1整合素在食管鳞癌中的阳性表达率(61.67%)较正常粘膜(90.00%)低,但无显著性差异(P>0.05);在浸润至全层组β1整合素的阳性表达率(20.83%)显著低于浸润至肌层组(50.00%)(P<0.05);在淋巴结移组其阳性表达率(43.48%)显著低于无淋巴结转移组(72.97%)(P<0.05)。结论β1整合素的低表达可能是食管鳞癌浸润和淋巴结转移的原因之一。

Expression of β1 integrin and its association with biological behavior in esophageal squamous cell carcinoma

Objective To determine the expression of β1 integrin in esophageal squamous cell carcinoma,and explore their association with clinical biological behavior to provide the theoretical basis for gene therapy and prognosis judgement in esophageal squamous cell carcinoma.Methods The expression of β1 integrin was detected by immunohistochemical method in 10 cases of normal esophageal mucosa and 60 cases of esophageal squamous cell carcinoma.Results The positive expression rate of β1 integrin in esophageal squamous cell carcinoma(61.67%)was lower than that in normal mucosa epithelium(90.00%),but there was no significant difference between them(P>0.05).The positive expression rate of β1 integrin in the group invaded to the whole wall(20.83%) was lower than that in the group invaded to muscularis(50.00%,P<0.05),and its positive rate in the group with lymph node metastasis(43.48%) was much lower than that in the group without lymph node metastasis(72.97%,P<0.05).Conclusion The lower expression of β1 integrin may be one of reasons for invasion and metastasis of esophageal squamous cell carcinoma.