施他宁善得定及垂体后叶素治疗AGVB的疗效对比

目的:评价施他宁、善得定、垂体后叶素治疗急性食管胃底静脉曲张破裂出血(AGVB)的疗效和不良反应。方法:选择57例肝硬化并AGVB患者随机分为3组,分别使用施他宁、善得定、垂体后叶素治疗,记录3组的止血效果和不良反应。结果:施他宁、善得定和垂体后叶素均能有效控制AGVB,治疗总有效率分别为82.61%、81.25%、77.78%,组间比较差异无显著性(P>0.05)。施他宁组和善得定组仅有轻微不良反应。结论:施他宁、善得定治疗AGVB的疗效与垂体后叶素差异无显著性,但在无正确的禁忌证应首选垂体后叶素。

Efficacy and safety of somtostatin and its derivative versus pituitrin in patients with acute gastroesophageal variceal bleeding

Objective:To assess the efficacy and safety of somatostatin and its derivative in the treatment of acute gastroesophageal variceal bleeding(AGVB).Methods:Fifty-seven patients with AGVB were randomly divied into 3 groups,which received either stilamin(n=23) or sandostatin(n=16) or pituitrin(n=18) respectively.The results of hemostasis and all side effects were recorded throughout therapy.Results:All stilamin,sandostatin and pituitrin were effective in controlling AGVB.82.61%,81.25% and 77.78% of patients in each group were considered to be effective with no statistically significant difference(P>0.05) among the three groups.Both stilamin and sandostatin had mild adverse effects.Conclusion:The efficacy of somatostatin and its derivative was similar to pituitrin in controlling AGVB due to cirrhosis,but their toleration and safety were superior to pituitrin.