SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma |
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| Authors: | Yuan-Yuan Kang Fu-Li Sun Ying Zhang Zhe Wang |
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| Affiliation: | 1. Department of Emergency and Oral Medicine, The School of Stomatology, China Medical University & Liaoning Institute of Dental Research & Liaoning Province Key Laboratory of Oral Diseases & Liaoning Province Translational Medicine Research Center of Oral Diseases, Shenyang, Liaoning, China;2. Department of Pathology, The Second Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China |
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| Abstract: | BackgroundOral squamous cell carcinoma (OSCC) is the most common malignant tumor in oral cancer, however, the mechanism underlying OSCC tumorigenesis is unknown. SIRT1, has been considered a prominent tumor-suppressing/promoting gene in various solid tumors, although the precise role of SIRT1 in OSCC progression remains unknown.MethodsSIRT1 expression was assessed in surgically resected specimens from patients with OSCC for histopathologic factors. SIRT1 levels in OSCC were determined, SIRT1 overexpression was achieved on transfecting OSCC cells with a SIRT1-containing plasmid, followed by evaluation of proliferative ability and invasiveness of these cells.ResultsSIRT1 levels were significantly lower in patients with OSCC than in controls (p < 0.05). Moreover, SIRT1 levels in patients with OSCC were significantly associated with the lymphovascular permeation but not with the sex, age, stage and location. Furthermore, SIRT1 overexpression inhibited proliferation and invasion in OSCC cells.ConclusionThe present results suggest that SIRT1 is a potential tumor suppressor in OSCC. |
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| Keywords: | Invasion Oral cancer Proliferation Corresponding author. Dr. Yuan-Yuan Kang, Department of Emergency and oral medicine, school of Stomatology, China Medical University, 117, Nanjing North Street, Shenyang, Liaoning 110002, China. |
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