Antinociceptive and pronociceptive effect of levetiracetam in tonic pain model |
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| Authors: | José Luis Cortes-Altamirano Samuel Reyes-Long Adriana Olmos-Hernández Herlinda Bonilla-Jaime Paul Carrillo-Mora Cindy Bandala Alfonso Alfaro-Rodriguez |
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| Affiliation: | 1. PhD Program in Biological and Health Sciences, Universidad Autónoma Metropolitana (UAM) Iztapalapa-Xochimilco-Cuajimalpa, Mexico City, Mexico;2. Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, Estado de México, Mexico;3. Department of Neurosciences, National Rehabilitation Institute “Luis Guillermo Ibarra Ibarra” (INR) Secretaría de Salud (SSA), Mexico City, Mexico;4. Departament of Reproductive Biology, Universidad Autónoma Metropolitana (UAM) Campus Iztapalapa, Mexico City, Mexico |
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| Abstract: | BackgroundLevetiracetam (LEV) is a novel anticonvulsant with proven antinociceptive properties. However, the antinociceptive and pronociceptive effect of this drug has not yet been fully elucidated in a tonic pain model.MethodsThirty-six male rats (Wistar) were randomized into six groups and underwent the formalin test as follows: rats in the control group were administered 50 μL of 1% formalin in the paw; sham-group rats were administered 50 μL of saline in the paw to mimick the application of formalin; the four experimental groups were administered LEV intragastrically (ig) (50, 100, 200 and 300 mg/kg), and 40 min later 50 μL of 1% formalin was injected in the paw.ResultsLEV exhibited antinociceptive effect in the 300 mg/kg LEV group (p < 0.05) and a pronociceptive effect in the 100 mg/kg LEV group (p < 0.05) and in the 50 mg/kg LEV group (p < 0.001).ConclusionsThe antinociceptive and pronociceptive effect of LEV in a tonic pain model is dose-dependent. |
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| Keywords: | Levetiracetam Antinociceptive Pronociceptive Tonic pain Rat |
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