| A—LAK,CD3—AK细胞体外对人小细胞肺癌细胞株的杀伤实验研究 |
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| 引用本文： | 朱争艳,付立.A—LAK,CD3—AK细胞体外对人小细胞肺癌细胞株的杀伤实验研究[J].天津医药,1999,27(7):406-408. |
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| 作者姓名： | 朱争艳 付立 |
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| 作者单位： | 天津市第三中心医院 300170
(朱争艳，付立，周立波)，天津市第三中心医院 300170(丁贤) |
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| 摘 要： | 目的：通过体外杀伤实验，比较ＬＡＫ，Ａ－ＬＡＫ，ＣＤ３ＡＫ细胞对人小细胞肺癌细胞株ＬＥＰＴ－ｓｍｌ的杀伤活性。方法：利用脐带血制备ＬＡＫ，Ａ－ＬＡＫ，ＣＤ３３ＡＫ细胞，观察其增殖、细胞表面ＩＬ－２Ｒ表达、细胞表型改变及对ＬＥＰＴ－ｓｍｌ细胞的细胞毒作用。结果：Ａ－ＬＡＫ，ＣＤ３ＡＫ比ＬＡＫ细胞具有更强的增殖能力的抗瘤活性。结论：Ａ－ＬＡＫ，ＣＤ３ＡＫ具有增殖能力和肿瘤杀伤能力强的优点，临床应用潜力
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| 关 键 词： | CD3AK细胞 肺肿瘤 小细胞肺癌 生物疗法 LAK细胞 |
The Cytotoxicity of LAK,A-LAK,CD_3AK Cells on Sclc Cell Line LEPT-sml |
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| Zhu Zhengyan,Fu Li,Zhou Libo,et al.The Cytotoxicity of LAK,A-LAK,CD_3AK Cells on Sclc Cell Line LEPT-sml[J].Tianjin Medical Journal,1999,27(7):406-408. |
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| Authors: | Zhu Zhengyan Fu Li Zhou Libo |
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| Abstract: | To study the killer activity of LAK, A-LAK, and CD_3 AK on scle cell line LEPT-sml in vitro. Methods: Lymphocytes derived from cord blood were prepared for LAK,A-LAK and CD_3 AK. Their activity of proliferation, expression of IL-2R in the cell surface and varieties of the T subset were observed. The effects of cytotoxicity on sclc cell line LEPT-sml were determined. Results: There was stronger proliferation and antitumor activity with A-LAK and CD_3 AK than LAK cells. conclusion: A-LAK and CD_3 AK cells had advantages of stronger proliferation and antitumor activity. There was more potential for clinical application. |
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| Keywords: | killer cells lymphokine activated antigens CD_3 carcinoma small cell lung neoplasms |
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