人乳头瘤病毒感染与宫颈疾病的关系

目的：探讨不同类型人乳头瘤病毒感染与宫颈病变的关系。方法：应用聚合酶链反应（ＰＣＲ）技术对２５３例妇科感染门诊患者进行人乳头瘤病毒（ＨＰＶ）分型检测。结果：ＨＰＶＤＮＡ总阳性率为５２．３％。其中慢性宫颈央组阳性率为１６．７％、假性湿疣组为２９．８％、疣样病变组为３７．５％、尖锐湿疣（ＣＡ）组为６１．７％、宫颈上皮内启样病变（ＣＩＮ）组为７９．７％、宫颈癌（ＣＣ）组为９０．９％。ＣＡ、ＣＩＮ及ＣＣ组ＨＰＶ检出率明显高于慢性宫颈炎组（均Ｐ＜０．０１）。结论：女性生殖道ＨＰＶ感染率随宫颈病变程度的加重呈现升高趋势，表明宫颈癌及其癌前病变的发生与ＨＰＶ感染密切相关。

Relationship between HPV Infection and Cervical Cancer

To evaluate the relationship between different types HPV infection and cervical malignant lesions. Meth- ods:Different types of human papilloma virus(HPV) were detected fm 253 Patients using polymerase chain reaction (PCR)techniques in the present study. Results: The total positive rate for HPV DNA was 52 .3%, the positive rates inchronic cervicitis, pseudocondyloma, condyloma-like lesions, condyloma acuminate (CA), cervical intra-epithelial neoplasia (CIN)and cervical cancer(CC)groups were 16.7%, 29 .8%, 37.5%, 61 .7%, 79. 7% and 90. 9% resistively. Positiverates of HPV in CA,CIN and CC groups were significantly higher than that in cervicitis group(P < 0. 01 ). Conclusion: HPV infections were strongly correlated with cervical cancer and CIN. HPV infections in female genital tract were involed in pre-cancerous cervical lesions.