Ⅱ型糖尿病血浆氧化修饰低密度脂蛋白,载脂蛋白E的改变

采用单抗ＥＬＩＳＡ法测定了４０例Ⅱ型糖尿病患者及２０例正常对照组血浆ＯＸ－ＬＤＡ、ＡｐｏＥ水平。结果显示：（１）ＤＭ组较对照组ＯＸ－ＬＤＬ、ＡｐｏＥ水平显著增高（Ｐ〈０．０１，Ｐ〈０．０５）。ＤＭ伴血管病变组与无血管病变组比较，前者血浆ＯＸ－ＬＤＬ、ＡｐｏＥ水平显著增高（Ｐ〈０．０５）。（２）２０例Ⅱ型糖尿病患者经力平脂治疗后血浆ＯＸ－ＬＤＬ、ＡｐｏＥ水平显著下降。（３）血浆ＯＸ－ＬＤＬ与血ｃｈ、

Changes of the Plasma Oxidated Low Density Lipoprotein and Apolipoprotein E in Non-Insulin-Dependent Diabetes Mellitus Patients

The level of plasma oxidated low density lipoprotein (OX-LDL), apolipoprotein E(ApoE) were measured by single antibody enzyme linked immunosorbent assay in 40 non-insulin-dependent diabetes mellitus (NIDDM) patients and in 20 normal subjects. Changes of the plasma OX-LDL,ApoE were also observed in 20 NIDDM patients treated with fenofibrate. Results: The plasma OX-LDL, ApoE concentration were higher in NIDDM patients than those in controls (P < 0. 01, P < 0 .05). The level of plasma OX-LDL, ApoE in 22 NIDDM patients with vascular disease increased significantly in comparison with those in 18 NIDDM patients without vascular disease (P < 0 .05). The level of plasma OX-LDL, ApoE also markedly reduced in 20 NIDDM patients after the treatment with fenofibrate (P< 0. 05). There was no significant correlation between the level of plasma OX-LDL and serum cholesterol, triglyceride, high density lipoprotein, ApoE. Conclusion: It was suggested that elevated OX-LDL might be a risk factor related to vascular disease in NIDDM patient. Fenofibrate might take effect in preventing NIDDM patient from the development of vascular disease.