小儿哮喘氯喹非松疗法的抗炎机理及临床疗效

目的：研究氯喹非松（ＣＰＰ）疗法的抗炎机理及疗效。方法：８２例哮喘患儿随机分为ＣＰＰ组和对照组，观察ＣＰＰ组治疗前后ＰＥＦ和ＰＤ２０＝－ＰＥＦ的变化，并行两组疗效比较。６０只豚鼠分为６组，致敏后的给药并收集支气管肺泡灌洗液（ＢＡＬ），行ＷＢＣ和Ｅｏｓ计数，结果：（１）ＣＰＰ组经ＣＰＰ治疗后，哮喘的临床控制率为７３．０８％，显效２１．１５％，好转 ５．７８％，无效为０。对照组分别为３、１１、１４和２

Observation Of Anti-Inflammatory Mechanisms and Clinical Efficacy of CPP Therapy in Asthmatic Children

To observe anti-inflammatory mechanisms and clinical efficacy of chloroquine, phenergan and prednisone (CPP)therapy. Method:82 cases of asthmatic children were randomly davided into CPP group and control group. Before and after treatment, the changes of PEF and PD20 PEF in the CPP group were observed. Clinical efficacy in the 2 groups were compared. 60 guinea pigs were divided into 6 groups. After being sensitized , various drugs and doses were used, following BALF collection. Results: In clinical asthma-control rate, there was significant difference between the CPP group(38/52)and. control group(3/30,x2 = 30 .28, P<0 .001 ). After treatment, PEF and PD20 PEF incresed greatly in the CPP group(t = 62.08, 173.94, P< 0. 01 ). WBC and the value in the BALF. Suggested that choroquine can be used to replace half the dosage of prednisone. Conclusion: The effect of CPP therapy is satisfactory in the treatment of asthmatic children. The experiment of asthmatic animal model has proved its strong anti-inflammatory effect.