溃疡贴片的研制与临床观察

目的　增加片剂对口腔粘膜的粘附力 ,延长药剂在口腔内的滞留时间及其中的药物的释放速度以提高药效。方法　通过加入生物粘附剂并进行有关质量的检测及临床观察与不加生物粘附剂的普通片剂进行对照。结果　该制剂粘附力强 ,吸水膨胀后可粘附于口腔溃疡的创面上 ,不易移动 ,既可起到治疗作用 ,又可保护创面 ,维持较长的药效。结论　该片剂疗效显著 ,使用方便。

Development and Clinical Observation of Kuiyang Adhesive Tablets

Objective The purpose is to increase bioadhesive strength of mucoadhesive sustained-release tablets and to prolong the residence time of the dosage form in oral cavity as well as the release rate of drug from the formulation so as to improve the effect of drug. Methods The bioadhesive agents were added to the tablets. Compared with that of ordinary tablets ,the qualities of the tablets were tested and the clinical curative effect of the tablets was observed.Results The adhesive force of the tablets was strong. After absorbing water and swelling ,the tablets can be adhered to the wound of ulcer and can not be easily moved.The tablets can make the curative effects as well as protect the wound and maintain longer the curative effects.Conclusion The curative effects of the tablets are remarkable and the method of use is convenient.