Additive effects of <Emphasis Type="Italic">LPL</Emphasis>, <Emphasis Type="Italic">APOA5</Emphasis> and <Emphasis Type="Italic">APOE</Emphasis>variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Additive effects of LPL, APOA5 and APOEvariant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study

Authors:	María-José Ariza Miguel-Ángel Sánchez-Chaparro Francisco-Javier Barón Ana-María Hornos Eva Calvo-Bonacho José Rioja Pedro Valdivielso José-Antonio Gelpi Pedro González-Santos

Affiliation:	1.Departamento de Medicina y Dermatología, Facultad de Medicina, Laboratorio de Lípidos y Arteriosclerosis, Centro de Investigaciones Médico-Sanitarias (CIMES),Universidad de Málaga,Málaga,Spain;2.Ibermutuamur Cardiovascular Risk Assessment (ICARIA) Study Group, Ibermutuamur: Mutua de Accidentes de Trabajo y Enfermedades Profesionales de la Seguridad Social n° 274,Madrid,Spain;3.Departamento of Medicina Interna,Hospital Universitario Virgen de la Victoria,Málaga,Spain;4.Departamento de Bioestadística, Facultad de Medicina,Universidad de Málaga,Málaga,Spain

Abstract:	Background Hypertriglyceridemia (HTG) is a well-established independent risk factor for cardiovascular disease and the influence of several genetic variants in genes related with triglyceride (TG) metabolism has been described, including LPL, APOA5 and APOE. The combined analysis of these polymorphisms could produce clinically meaningful complementary information.

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