Additive effects of <Emphasis Type="Italic">LPL</Emphasis>, <Emphasis Type="Italic">APOA5</Emphasis> and <Emphasis Type="Italic">APOE</Emphasis>variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study |
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| Authors: | María-José Ariza Miguel-Ángel Sánchez-Chaparro Francisco-Javier Barón Ana-María Hornos Eva Calvo-Bonacho José Rioja Pedro Valdivielso José-Antonio Gelpi Pedro González-Santos |
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| Institution: | 1.Departamento de Medicina y Dermatología, Facultad de Medicina, Laboratorio de Lípidos y Arteriosclerosis, Centro de Investigaciones Médico-Sanitarias (CIMES),Universidad de Málaga,Málaga,Spain;2.Ibermutuamur Cardiovascular Risk Assessment (ICARIA) Study Group, Ibermutuamur: Mutua de Accidentes de Trabajo y Enfermedades Profesionales de la Seguridad Social n° 274,Madrid,Spain;3.Departamento of Medicina Interna,Hospital Universitario Virgen de la Victoria,Málaga,Spain;4.Departamento de Bioestadística, Facultad de Medicina,Universidad de Málaga,Málaga,Spain |
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| Abstract: | Background Hypertriglyceridemia (HTG) is a well-established independent risk factor for cardiovascular disease and the influence of several
genetic variants in genes related with triglyceride (TG) metabolism has been described, including LPL, APOA5 and APOE. The combined analysis of these polymorphisms could produce clinically meaningful complementary information. |
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