Multiple micromanipulations for preimplantation genetic diagnosis do not affect embryo development to the blastocyst stage |
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Authors: | Cieslak-Janzen Jeanine Tur-Kaspa Ilan Ilkevitch Yuri Bernal Alejandra Morris Randy Verlinsky Yury |
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Institution: | aIVF and Preimplantation Genetics Diagnosis Program, Reproductive Genetics Institute, Chicago, Illinois |
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Abstract: | To determine the impact of multiple micromanipulation procedures for preimplantation genetic diagnosis (PGD) on embryo development, a retrospective analysis was performed of 9,925 embryos (862 PGD cycles), which were compared with 28,126 nonbiopsied embryos (2,751 consecutive intracytoplasmic sperm injection ICSI] cycles) from the same time period. Because fertilization rates, the proportion of embryos with > or = 6 cells on day 3, and blastocyst rates were similar in the PGD and control groups, we conclude that multiple micromanipulations on oocytes and embryos can be performed safely for PGD. |
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