多囊卵巢综合征年轻不孕患者体外受精-胚胎移植结局研究

目的 探讨对<35岁多囊卵巢综合征（PCOS）不孕患者行体外受精-胚胎移植 (in vitro fertilization and embryo transfer, IVF-ET)受孕后的结局。方法 选取2007年10月至2010年8月间在中山大学附属第一医院生殖中心第一次行IVF的<35岁PCOS患者共68例，对照组为<35岁的第一次行IVF的输卵管性不孕患者共1164例。对两组患者的基本资料、IVF-ET周期的卵子和胚胎情况以及妊娠结局进行回顾性比较。结果　<35岁PCOS患者IVF周期中的临床妊娠率（30.9% vs. 44.1%）、流产率（14.3% vs.12.9%）、多胎率（42.9% vs. 38.4%）、早产率（22.2 %vs.14.7%）、小于胎龄儿（9.5% vs.11.1%）以及大于胎龄儿（9.5% vs. 3.1%），与对照组患者比较，差异无统计学意义（P>0.05），但其妊娠期糖尿病（14.3% vs.4.1%）以及妊娠期高血压疾病（4.0% vs. 1.0%）的发生率高于对照组，差异有统计学意义（P<0.05）。结论 <35岁PCOS不孕患者行IVF-ET治疗后的妊娠期糖尿病、妊娠期高血压疾病的发生率增加。

Pregnancy outcomes of young patients with polycystic ovary syndrome after in vitro fertilization and embryo transfer.

Abstract： Objective To investigate the pregnancy outcome women with age <35 years polycystic ovary syndrome (PCOS) compared with control groups after in vitro fertilization and embryo transfer (IVF-ET). Methods Women with PCOS who underwent the first time of IVF between October 2007 and August 2010 were considered. A total of 68 PCOS patients and 1164 patients with tubal infertility were included, and reviewed focusing on the basal characteristics, IVF-ET outcomes, and pregnancy outcomes. Results The clinical pregnancy rate（30.9% vs. 44.1%）, miscarriage rate (14.3% vs. 12.9%), multiple pregnancy rate (42.9% vs. 38.4%), preterm delivery rate (22.2% vs. 14.7%), small for gestational age (SGA) (9.5 %vs. 11.1%) infant and large for gestational age (LGA) infant (9.5% vs. 3.1%) rate were not different between two groups (P>0.05). On the other hand, the morbidity of gestational diabetes mellitus (GDM) (14.3% vs. 4.1%) and hypertensive disorder complicating pregnancy (HDCP) (4.0% vs. 1.0%) was significantly higher than those in control group (P<0.05). Conclusion Age <35 years PCOS patients after IVF-ET did not present various higher pregnancy complications, but they presented some worse pregnancy outcomes, especially in GDM and HDCP.