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Therapy selection of autoimmune hemolytic anemia in children.

??Abstract??Autoimmune hemolytic anemia ??AIHA?? is an uncommon acquired immune disorder. The classification of AIHA is based on the pattern of the direct antiglobulin test and on the immunochemical properties of the autoantibody?? but also on the presence or absence of an underlying condition or disease. Different type of AIHA has different treatment and outcome. Treatment for AIHA has long been empirical and first line therapy is corticosteroids?? especially for warm AIHA ??wAIHA??.For relapsed or refractory AIHA?? second-line therapy??such as rituximab??may be a good alternative and has been more reported in childhood patients. In this article?? the classification and the recent progress in therapies for AIHA are discussed to provide treatment recommendations for pediatricians.