Tuberin Expression in Ganglioglioma |
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| Authors: | Yasuhiro Arai Cameron A. Ackerley Laurence E. Becker |
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| Affiliation: | 1. Department of Clinical Laboratory, Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan, and Division of Pathology, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada;2. Division of Pathology, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada |
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| Abstract: | The expression of tuberin in neurosurgically resected gangliogliomas was investigated. Neither neoplastic astrocytes nor abnormal, multipolar large neurons showed immunoreactivity for tuberin. The reduced immuno-histochemical staining for tuberin was consistent with the reduction observed in Western blot analysis. Eosinophilic granular bodies and Rosenthal fibers were strongly immunoreactive for tuberin. The accumulation of tuberin in astrocytes with intracellular degenerative changes suggests increased expression in reactive cells, and perhaps a broader role for tuberin in central nervous system disease. |
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| Keywords: | Ganglioglioma Hamartoma Tsc2 Gene Tuberin Tumor Suppressor |
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