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Bacterial etiology analysis of alveolar lavage fluid in severe pneumonia of 2044 children.

??Abstract?? Objective To investigate the distribution and antibiotic resistance of bacteriosis in alveolar lavage fluid in children’s severe pneumonia. Methods The strains isolated from alveolar lavage fluid in 2044 cases of severe pneumonia in children from Jan.2009 to Dec.2011 were retrospectively analyzed. Results In 2044 samples?? 247 strains were obtained. The dominant pathogenic bacteria were??49 strains of Klebsiella pneumoniae?? 44 Escherichia coli?? 23 Enterobacter cloacae?? 17 Pseudomonas aeruginosa?? 21 Streptococcus pneumoniae?? 11 Staphylococcus aureus and 9 Staphylococcus haemolyticus. The obtained strains had severe drug resistance to some antibiotics??which were penicillin G?? ampicillin?? amoxicillin clavulanic acid?? cefuroxime?? erythrocin?? and oxacillin?? but not to cefoperazone and sulbactam sodium. Conclusion The germiculture of alveolar lavage fluid by bronchoscopes is a better way for detecting pathogenic bacteria in the lower respiratory tract. The main pathogenic bacteria of the pediatric severe pneumonia are Gram-negative bacilli?? and it is important to early detect pathogenic bacteria and depress drug resistance improving curative effect and prognosis.