免疫调控在子痫前期早期干预中的作用和评价

子痫前期的发生与免疫失调有一定的关系。母胎界面免疫耐受异常使滋养细胞侵袭性下降，子宫螺旋小动脉的“重铸障碍”，导致病理性胎盘形成；自身免疫异常如抗磷脂抗体通过干扰依赖磷脂的各种凝血与抗凝血因子的功能，使凝血功能紊乱，胎盘微血栓形成，导致胎盘灌注量的下降。子痫前期的早期干预措施包括：对于有子痫前期高危因素的孕妇妊娠中期开始服用小剂量阿司匹林，有较好的预防作用；妊娠早期和中期应用低分子肝素治疗也有一定的疗效；各种免疫治疗和抗氧化治疗的效果缺乏循证医学证据。

Role of immune regulation in the early intervention of preeclampsia and its evaluation.

Abstract: The occurrence of preeclampsia and immune disorders have certain relations. Abnormal immune tolerance of maternal-fetal interface makes invasive trophoblast cells decrease and uterine spiral arteries of "recast obstacles"occur, leading to the formation of pathological placenta.There are various autoimmune abnormalities,for example,antiphospholipid antibody interferes with blood clotting and anticlotting factors,resulting in clotting disorders and placental micro thrombosis,which leads to decreased placental perfusion volume.Preeclampsia early intervention measures include:with risk factors,for pre-edampsia for pregnant women start taking low-dose aspirin in the middle trimester,which has a better preventive effect. During early and metaphase trimester of pregnancy,low-molecular weight heparin therapy also has a certain effect.The effect of various immune treatment and oxidation treatment lack evidence of evidence-based medicine.