基于CT数据人离体胎盘血管网数字化三维模型重建研究

目的 探讨利用CT原始数据进行人离体胎盘血管网数字化三维模型重建的方法及应用。方法   选取2012年5月南方医科大学南方医院妇产科人正常妊娠足月离体胎盘20例，胎盘动脉灌注后进行增强CT扫描并获取DICOM原始数据集，随后行胎盘静脉灌注，胎盘标本再次行增强CT扫描，得到DICOM原始数据集。将两次数据导入Mimics 10.01软件分别重建得到胎盘动脉血管网及胎盘动静脉血管网的数字化三维模型。对CT扫描后的胎盘标本进行强酸腐蚀，得到胎盘血管铸型。对比同一胎盘标本的血管网数字化三维模型及血管铸型，明确数字化三维模型反映胎盘血管形态结构及走行的真实性和准确性。结果   基于CT原始数据，利用Mimics 10.01软件成功构建出胎盘血管网数字化三维模型。重建得到的模型立体感强，三维效果逼真，具有较佳的视觉效果，与胎盘血管铸型一致性高，可以清晰地再现胎盘动静脉各级血管分支的解剖形态结构，且可进行任意缩放、任意角度旋转观察。结论   基于CT原始数据构建的胎盘血管网数字化三维模型可全面、真实地展示胎盘血管，是一种胎盘血管研究的新方法；该模型的建立为后续研究提供了一定的三维重建的技术基础。

Preliminary study on the methods and applications of reconstructing digital three-dimensional model of human placental vascular networks in vitro based on CT data.

Abstract： Objective To explore the methods and applications of reconstructing digital three-dimensional(3D) models of human placental vascular networks in vitro based on CT data. Methods Placentas from twenty healthy primiparas who delivered at term were given enhanced CT scan after placental arterial perfusion. We acquired the original DICOM two-dimensional tomographic image data set. Then we perfused the placental veins and performed enhanced CT scan to the perfused placentas again. The DICOM images were input into the Mimics 10.01 software. The Mimics 10.01 software was applied to reconstruct the digital 3D models of placental arterial networks and placental vascular networks. The placentas were corroded by strong acids after CT scan and then we got the placental vascular networks casting models. Subsequently, taking the placental vascular networks casting models as the standard, we evaluated the authenticity and accuracy of digital 3D models. Results Using the Mimics 10.01 software, we can successfully reconstruct the digital 3D models of placental vascular networks based on CT data. The digital 3D models are realistic and stereoscopic,presenting excellent visual effect and showing morphological structures of placental vascular networks clearly, which are highly consistent with the vascular casting models. The digital 3D models can not only be zoomed in or out but also be revolved freely for better observation of placental vessels. Conclusions The digital 3D models of placental vascular networks, which are reconstructed based on CT image data set, can fully display the placental vessels. It is a new and effective method to use the digital 3D models to study placental vascular networks, which serves as a technical foundation for further studies.